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Sulfonamides ulcerative colitis

Promoting an Optimal Response to Therapy The patient receiving a sulfonamide drug almost always lias an active infection. Some patients may be receiving one of Hiese drugs to prevent an infection (prophylaxis) or as part of Hie management of a disease such as ulcerative colitis. [Pg.62]

The answers are 484-k 485-j. (tlardman, pp 1061-1062, 1682-1685.) Sulfonamides can cause acute hemolytic anemia. In some patients it mayr be related to a sensitization phenomenon, and in other patients the hemolysis is due to a glucose-6-phosphate dehydrogenase deficiency Sulfamethoxazole alone or in combination with trimethoprim is used to treat UTls. The sulfonamide sulfasalazine is employed in the treatment of ulcerative colitis. Daps one, a drug that is used in the treatment of leprosy, and primaquine, an anti mala rial agent, can produce hemolysis, particularly in patients with a glucose-6-phosphate dehydrogenase deficiency. [Pg.279]

Lactation Sulfonamides are excreted in breast milk. In newborns, they compete with bilirubin for binding sites on the plasma proteins and may cause kernicterus. Children The safety and efficacy of sulfasalazine in pediatric patients younger than 2 years of age with ulcerative colitis have not been established. [Pg.1431]

Sulfasalazine (Azulfidine, Azulfidine EN) [Anti-inflammatory/ Antirheumatic (DMARD)/Sulfonamide] Uses Ulcerative colitis, RA, juvenile RA, active Crohn Dz, ankylosing spondylitis, psoriasis Action Sulfonamide actions unclear Dose Adults. Initial, 1 g PO tid-qid T to a max of 8 g/d in 3 -5- doses maint 500 mg PO qid Feds. Initial 40-60 mg/kg/24 h PO -s- q4-6h maint 20-30 mg/kg/24 h PO q6h RA >6 y 30-50 mg/kg/d in 2 doses, start w/ 1/4-1/3 maint dose, T wkly until dose reached at 1 mo, 2 g/d max -i in renal failure... [Pg.291]

Aminosalicylates, eg, mesalamine in many formulations Mechanism uncertain t may be inhibition of eicosanoid inflammatory mediators Topical therapeutic action systemic absorption may cause toxicity Mild to moderately severe Crohn s disease and ulcerative colitis Sulfasalazine causes sulfonamide toxicity and may cause GI upset, myalgias, arthralgias, myelosuppression other aminosalicylates much less toxic... [Pg.1332]

Administration Most sulfa drugs are well absorbed after oral administration. Sulfasalazine [sul fa SAL a zeen], when administered orally or as a suppository, is reserved for treatment of chronic inflammatory bowel disease (for example, Crohn s disease or ulcerative colitis), because it is not absorbed. Similarly, succinylsulfathiazole [suks in ill sul fa THI a zole] is used for the treatment of salmonella and shigella carriers. Intravenous sulfonamides are generally reserved for patients who are unable to take oral preparations. Because of the risk of sensitization, sulfas are not usually applied topically. In burn units, creams of mafenide acetate (p-aminomethylbenzensulfonamide) or silver sulfadiazine have been effective in reducing burn sepsis. However, superinfections with resistant bacteria or fungi may occur. [Pg.302]

The drug is practically insoluble in water (1 g in 10,000 ml). Thus, being poorly absorbed from the small intestine, SZ reaches the colon intact, where bacterial azo-reductase enzymes cleave the compound to its components sulfapyridine (SP) and 5-aminosali-cylic acid (5-ASA). In slow acetylators, where the absorption of SP can lead to plasma levels above 50 pg/ml. It is very likely that it is the sulfonamide that is responsible for the toxic adverse effects associated with SZ. It is ironic that the drug s suppressive effect on ulcerative colitis was at first attributed to the local antibacterial effect of SP. With the dis-... [Pg.162]

Sulfasalazine, a sulfonamide antibiotic (3 to 4 g p.o. daily in divided dosage), is indicated in the treatment of ulcerative colitis. [Pg.660]

Sulfonamides that are poorly absorbed. These agents include succinylsulfathiazole (Sulfasux-ide), phthalylsulfathiazole (Sulfathalidine), and sulfasalazine (Azulfldine) they are used as intestinal antiseptics. Sulfasalazine is used especially in the therapy of regional enteritis and ulcerative colitis (Figure 91). [Pg.662]

The remaining sulfonamides are not used systemically. Sulfadiazine in the form of its silver salt is used topically for treatment of burns and is effective against a range of bacteria and fungus. Sulfacetamide is used ophthalmically for treatment of eye infections caused by susceptible organisms, and sulfasalazine is a pro-drug used in the treatment of ulcerative colitis and Crohn s disease. [Pg.1574]


See other pages where Sulfonamides ulcerative colitis is mentioned: [Pg.272]    [Pg.314]    [Pg.274]    [Pg.3217]    [Pg.107]    [Pg.270]    [Pg.163]    [Pg.1575]    [Pg.109]    [Pg.89]   
See also in sourсe #XX -- [ Pg.619 ]




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