Sulfamethazine

Chemical Name 4-Amino-(M-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide 

Common Name Sulfamezathine, sulfadimerazine, sulfamidine, sulfadimethylpyrimidine, sulfadimidine (U.K. Name) 

Trade Name Manufacturer Country Year Introduced 

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Chemically synthesized antimicrobials used in animal and poultry feeds include arsenicals, eg, arsanilic acid [98-50-0] sodium arsanilate [127-85-5] and roxarsone [121-19-7]-, sulfa dmgs, eg, sulfadimethoxine [122-11-2], sulfamethazine [57-68-1], and sulfathiazole [72-14-0]-, carbadox [6804-07-5]-, and nitrofurans, eg, furazoHdone [67 5-8] and nitrofurazone [59-87-0] (see Antibacterial agents, synthetic Antiparasitic agents). 

A/ -HeterocycHc derivatives can be formed in some cases by a ring closure to give the heterocycle. Sulfadiazine, sulfamethazine, sulfamerazine, and sulfathiazole have been prepared in this fashion, but also by the usual procedure from the sulfonyl chloride and heterocycHc amine. The synthesis of sulfamethazine from sulfaguanidine is an example of the ring closure method. 

The components present in the mixture are as follows a/ sulfaguanidine, b/ sulfanilamide, c/ sulfadiazine, d/ sufathiazole, e/ sulphapyridine, it sulfamerazine, g/ sulfamethazine,... 

Test strip and immunoflltration devices were developed by Ostermaier et al to detect sulfadiazine, sulfamethazine, and sulfamethoxypyridazine in milk. Direct competitive immunoassay was utilized with sulfonamide-horseradish peroxidase as the detector. The LOD for sulfamethazine for both the dipstick and immunoflltration was 10 pg kg for sulfadiazine, the LOD was 12 pg kg for the dipstick and 30 pg kg for immunoflltration. For sulfamethoxypyridazine, the LOD was 10 pgkg for the dipstick and 20 pgkg for immunoflltration. The devices were found to be suitable for on-site use with undiluted milk. 

Lopez-Avila and Benedicto combined SEE with ELISA to determine sulfamethazine in powdered milk. Various conditions were tested in order to achieve quantitative extraction of sulfamethazine. Variations in extraction pressure, temperature, extraction period, and the presence of organic modifier resulted in extraction efficiencies of 0-92%. Once optimal extraction conditions had been developed, a commercially available ELISA was utilized to determine sulfamethazine concentrations. The LOD was 2.5 pgkg and satisfactory recoveries were obtained at levels from 5 to 15 pgkg-i. 

Berzas Nevado, J.J., Castaneda Penalvo, G., and Guzman Bernardo, F.J., Simultaneous determination of sulfaquinoxaline, sulfamethazine, and pyrimethamine by liquid chromatography, /. Chromatogr. A, 870 (1 2), 169,2000. 

Sulfanomides Sulfadimethaoxine, sulfamethazine, sulfamethoxazole, sulfadiazine, and sulfathiazole Urinary tract infections... 

Dolliver et al. [74] Managed pile (12 m3) and also in vessel composting units (rotating drum type) Turkey manure Chlortetracycline (CTC), monensin, sulfamethazine (SMZ) and tylosin (TYL)... 

The bioslurry treatment successfully removed several of the PhC to non-detectable levels after 26 days three histamine H2-receptor antagonists (ranitidine, famotidine, cimetidine), two (1-blockers (atenolol, sotalol), one barbiturate (butalbital) and one antidiabetic compound (glibenclamide). The elimination of the sulfonamide antibiotics sulfapyridine (100%), sulfamethazine (91.0%) and... 

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