Sodium arsanilate

Chemically synthesized antimicrobials used in animal and poultry feeds include arsenicals, eg, arsanilic acid [98-50-0] sodium arsanilate [127-85-5] and roxarsone [121-19-7]-, sulfa dmgs, eg, sulfadimethoxine [122-11-2], sulfamethazine [57-68-1], and sulfathiazole [72-14-0]-, carbadox [6804-07-5]-, and nitrofurans, eg, furazoHdone [67 5-8] and nitrofurazone [59-87-0] (see Antibacterial agents, synthetic Antiparasitic agents). 

Sodium arsanilate Subcutaneous injection of 70 mg/kg BW caused degeneration 6... 

Various phenylarsonic acids — especially arsanilic acid, sodium arsanilate, and 3-nitro-4-hydroxyphenylarsonic acid—have been used as feed additives for disease control and for improvement of weight gain in swine and poultry for almost 40 years (NAS 1977). The arsenic is present as As+5... 

The introduction of the arsinic acid group into the aromatic nucleus is of great interest in connexion with the therapeutic application of arsenic compounds in combating certain infectious diseases (atoxyl = sodium arsanilate salvorsan). 

The medicinal use of arsenic compounds is now very limited, but some are still used in human trypanosomiasis. The effect of heterocyclic groups in reducing toxicity is well shown in the trypanocide melarsoprol (Mel B) (263), in which the severe toxicity of sodium arsanilate (atoxyl) has been reduced successively by substitution with a triazine residue and incorporation of the arsenic atom in a heterocycle. 

Atoxyl (Sodium arsanilate) Trypoxyl Protoxyl Pentavalent 1905... 

Ossenkopp, K.-P., and Hargreaves, E. L. (1993). Spatial learning in an enclosed eight-arm maze in rats with sodium arsanilate-induced labyrinthectomies. Behavioral and Neural Biology, 59, 253-257. 

The toxicity of a given arsenical is related to the rate of its clearance from the body and therefore to its degree of accumulation in tissues. In general, toxicity increases in the sequence of organic arsenicals arsenicals contain arsenic covalently linked to a carbon atom, where arsenic exists in the trivalent or pentavalent state. Arsphenamine contains trivalent arsenic sodium arsanilate contains arsenic in the pentavalent form. The organic arsenicals usually are excreted more rapidly than are the inorganic forms. 

Various phenylarsoiuc acids - especially arsanilic acid, sodium arsanilate, and 3-nitro-4-hydroxyphenylarsonic acid-have been used as feed additives for disease control and for improvement of weight gain in swine and poultry for more than 50 years. The arsenic is present as As" " and is rapidly excreted present regulations require withdrawal of arsenical feed additives 5 days before slaughter for satisfactory depuration. Under these conditions, total arsenic residues inedible tissues do not exceed the maximum permissible limit of 2.0 mg/kg FW. Organoarseiucals probably will continue to be used as feed additives unless new evidence indicates otherwise. 

Aminophenyl) arsonic acid, monosodium salt (4-Aminophenyl) arsonic acid, sodium salt. See Sodium arsanilate [8-[(p-Aminophenyl) azo]-7-hydroxy-2-naphthyl] trimethylammonium chloride. See Basic brown 16... 

Lanolin USP Ultrafine, Anhydrous Lanolin USP, Anhydrous lanolin. See Lanolin Anhydrous sodium srsanilate. See Sodium arsanilate... 

Arsinic acid, dimethyl-. See Cacodylic acid Arsinosolvin. See Sodium arsanilate Arsonic acid, (4-hydroxy-3-nitrophenyl)-. See 4-Hydroxy-3-nitrophenyl arsonic acid Arsonic acid, methyl-, disodium salt. See Disodium methanearsonate Arsonic acid, methyl-, monosodium salt. See Sodium acid methanearsonate Arsonic acid, potassium salt. See Potassium arsenite... 

Sodium 4-ami nobenzoate Sodium p-aminobenzoate. See Sodium aminobenzoate Sodium 2-amino-4,6-dinitrophenoxide. See Sodium picramate Sodium 6-amino-4-hydroxy-5-((2-(trifluoromethyl) phenyl) azo) naphthalene-2-sulfonate. See Acid red 337 Sodium aminophenyl arsonate Sodium p-aminophenylarsonate. See Sodium arsanilate Sodium amino tri (methylene phosphonic acid) ... 

Sodium Antimonate Poly Grade, Sodium antimony. See Sodium antimonate Sodium arsanilate CAS 127-85-5... 

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