Study parallel fixed-dose

Risperidone fulfills the atypical criterion of having a low incidence of EPS at low to moderate doses. The mean optimal dose in parallel, fixed-dose studies was 4 to 6 mg daily. At doses greater than 6 mg daily, risperidone s profile is more similar to that of an FGA. Because risperidone appears to lose its atypical profile at higher doses, the lowest possible dose should be used in treatment. This may include gradual dose titration downward if patients do not respond initially, rather than upward titration as has been the traditional approach to dosing antipsychotics. ... 

Acitretin is also available for use in psoriasis, although there is no consensus on its optimum effective dose with acceptable side effects. A randomised, double-blind, parallel-group, dose ranging study (three fixed doses in adult patients) was carried out [2 ]. This investigation included patients of either gender (age range, 18-65 years) with severe chronic plaque-type psoriasis. 

Tollefson et al. (1994] reported an American multicenter investigation of fixed-dose fluoxetine in the treatment of OCD. Three hundred fifty-five outpatients participated in two randomized, double-blind, parallel, 13-week trials, receiving fluoxetine or placebo. Fluoxetine (20 mg, 40 mg, and 60 mg] was significantly superior to placebo on the Y-BOCS total score and other efficacy measures. However, a trend was noted suggesting greater efficacy of the 60 mg/day dose. The authors reported few side effects, and most patients (79.2%] completed the study. Similarly to CMl, fluoxetine led to a significant reduction in OCD severity, regarding both obsessions and compulsions. 

Numerous clinical trials have also attested to the anxiolytic efficacy of hydroxyzine. Controlled trials have confirmed its efficacy and safety at a fixed dose of 50 mg in GAD (64). In a double-blind, parallel-group, multicenter study in France and Great Britain, a total of 244 patients with GAD were allocated randomly to treatment with hydroxyzine (12.5 mg t.i.d.), buspirone 5 mg morning and midday and 10 mg in the evening, or placebo. The results showed both hydroxyzine and buspirone to be more efficacious than placebo, indicating that hydroxyzine can be a useful treatment for GAD (65). 

Singh and coworkers (1998) reported a randomized, double blind placebo-controlled, fixed-dose study of kava (Kavatrol ) within a parallel groups design. Sixty... 

Dogra S, Jain A, Kawar AJ. Efficacy and safety of acitretin in three fixed doses of 25,35 and 50 mg in adult patients with severe plaque type psoriasis a randomized, double-blind, parallel group, dose ranging study. J Eur Acad Dermat Ven 2013 27(3) e305-ll. 

A description (e.g., in a table) of studies. Xia et al. (2011) provide an example of such a table. At a minimum, the table should include the planned Phase 2 and 3 studies. The description of studies includes study design (e.g., fixed versus flexible dose, parallel versus crossover), dosing schedule, study location, treatment groups and doses, number of subjects planned (by treatment group and doses), patient population (e.g., based on planned indication, special age groups), and duration of study. 

Diener HC, et al. The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalgia 2005 25 776-787. 

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