Streptozotocin, lipid metabolism

Whiting, P.H., Palmano, K.P., and Hawthorne, J.N., 1979, Enzymes of myo-inositol and inositol lipid metabolism in rats with streptozotocin-induced diabetes. Biochem. J. 179 549-553. 

Sahin K, Onderci M, Tuzeu M, Ustundag B, Cikim G, Ozercan IH, Sriramoju V, Juturu V, Komorowski JR. Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus the fat-fed, streptozotocin-treated rat. Metabolism. 2007 56 1233 0. 

In compensation for this abnormal situation, fat is preferentially used as a sole energy source in the body. The metabolic shift to lipid utilization leads to hypertriglyceridemia accompanied by elevation of free fatty acid in blood and, in very advanced stages by elevation of ketone bodies including acetoacetate and 3-hydroxy-butyrate in blood. Increased level of CoA and acyl CoA in the diabetic rat liver was reported by Smith et al. [1]. This seems to be a metabolic response to increased utilization of fatty acid in diabetic state and suggests increased requirement for CoA in diabetic tissues. It is, therefore, interesting to study the effect of some precursors of CoA on diabetic hyperlipidemia. The present paper deals with a favorable effect of pantethine on lipid metabolism in streptozotocin diabetic rats. Pantethine treatment has been found to reduce increased levels of serum triglycerides,... 

T. Yokozawa, H. Y. Kim, and E. J. Cho, Erythritol attenuates the diabetic oxidative stress through modulating glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats, J. Agric. Food Chem., 2002, 50, 5485-5489. 

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