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Steroids structural chemistry

Yakushiji, T., Sakai, K., Kikuchi, A., Aoyagi, T., Sakurai, Y, Okano, T. (1999). Effects of cross-linked structure on temperature-responsive hydrophobic interaction of poly(lV-isopropylacrylamide) hydrogel-modified surfaces with steroids. Analytical Chemistry, 71, 1125-1130. [Pg.44]

Miscellaneous Chemistry - Several other new steroid structures were prepared by a variety of synthetic routes. Among these are 8,19"OXI do-steroids, 9a-amino-11-oxygenated steroids, a variety of 21-substituted-17-viny 1 i dine steroi ds, a 17B-, l8-cyclosteroid,... [Pg.186]

Classical or conventional pharmaceutical agents in combination with lactide/glycolide polymers have been widely studied since about 1973. In general, these compounds are bioactive agents usually produced by synthetic chemistry, with molecular weights of less than a few hundred and relatively stable structures. Examples include steroid hormones, antibiotics, narcotic antagonists, anticancer agents, and anesthetics. [Pg.15]

In addition to the challenges cited above, there are some special issues associated with steroid chemistry that should be noted. The steroidal impurities formed in the process are generally similar in structure to the desired product and, in some cases, co-crystallization with the product is a problem. It is, therefore, critical to limit the formation of steroidal impurities in the reactions. The structural similarity between product and impurities also creates challenges in developing assays for reaction monitoring and purity determination. Furthermore, the poor solubility of these compounds in the solvents typically used in a manufacturing process makes it very difficult to achieve practical volume productivity in process development. [Pg.80]

Sir Derek H. R. Barton (1918-1998, formerly Distinguished Professor of Chemistry at Texas A M University) and Odd Hassell (1897-1981, formerly Chair of Physical Chemistry of Oslo University) shared the Nobel prize in 1969 for developing and applying the principles of conformation in chemistry. Their work led to fundamental understanding of not only the conformations of cyclohexane rings, but also the structures of steroids (Section 23.4) and other compounds containing cyclohexane rings. [Pg.158]

The unique molecular skeleton of the C-nor-D-homosteroids represents significant challenges for organic chemists. The structure elucidation and the total synthesis of cyclopamine (3, also known as 11-deoxojervine), jervine (ll-oxo-3), and veratramine (4) are important milestones in steroid chemistry. Many synthetic strategies were developed in the 1960s-1970s for these targets. Notably, Masamune... [Pg.26]

Atta-ur-Rahman and Choudhary, M.I., 1988, Structural studies on new steroidal alkaloids of Buxus papillosa. In Studies in Natural Products Chemistry (Atta-ur-Rahman ed.), Elsevier Science, Amsterdam, Vol. 2, pp 175-189. [Pg.65]

Diels-Alder reactions have long played an important role in synthetic organic chemistry. The reaction of a substituted benzoquinone and 1,3-butadiene, for example, was the first step in one of the early syntheses of steroids. The angular methyl group is introduced from the quinone, and the other functional groups were used for further structural elaboration. [Pg.339]

Steroid [75] and terpene [76] chemistry is undoubtedly a challenging topic of research that drives hundred of investigators all around the world. Terpenes are a large and structurally diverse family of natural products comprising C5 isoprene... [Pg.153]

This chapter reviews the year s published work on physical and analytical aspects of steroid chemistry. No attempt has been made to survey the enormous number of routine applications of spectroscopic methods to structure determination. Attention has been concentrated mainly upon those developments of a fundamental nature which increase our understanding of the physical techniques and the phenomena which they explore. The major advances reported this year in the area of spectroscopy lie in the interpretation and applications of Cn.m.r. tritium n.m.r. has made its appearance as a method for the analysis of labelled steroids. The short sections on analytical methods give the Reviewer s selection of significant advances in radioimmunoassay and chromatographic methods of interest to chemists. [Pg.211]

Minor changes in the stereochemistry and substitution pattern of the steran skeleton result in vastly different yet specific physiological and pharmacological effects, which in turn influence developmental, metabolic, and behavioral phenomena. The organic chemistry and biochemistry of steroids is the subject of many excellent books and an enormous amount of research and patent literature. This chapter compares and contrasts the structure and mode of action of various steroids, their role in regulating hormonal secretion, and the timing of this regulatory action. [Pg.312]

Although steroids have been studied for many years, steroid hormones continue to be a rich area of medicinal chemistry study. Steroids continue to be evaluated for their therapeutic role in the treatment of cancer, especially malignancies whose growth characteristics are hormonally responsive. In recent years, the increased recognition of the role of steroids in the brain has resulted in ongoing projects to evaluate steroids as general anasthetics and anticonvulsants. Also, the search for compounds that bind to steroid receptors, but which are not steroidal in their molecular structure, is another important area of research. [Pg.381]

Cholesterol is the prototypic steroid lipid. It was first isolated in 1770 in the 1920s, the German chemists Windaus and Wieland deduced the structure for cholesterol, receiving Nobel Prizes for their work in 1927 and 1928. Cholesterol is important in medicinal chemistry, not only for its role in atherosclerosis, but also because it is an important lipid in membrane structure. [Pg.474]

Indolizidine is the alkaloid S-coniceine and this nucleus has been observed in several groups of alkaloids. Since the chemistry of alkaloids deriving from indolizidines and partially unsaturated indolizidines is reported regularly (B-81MI30800, B-79MI30800), only selected examples will be taken from the natural products field. Structurally more complex alkaloids such as (217), (218) and indolizidine aza steroids (81H(16)1093,81H(16)1097), which may often be assigned to other groups of alkaoids as well, are not mentioned. [Pg.476]


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See also in sourсe #XX -- [ Pg.227 , Pg.228 , Pg.229 , Pg.230 , Pg.231 , Pg.232 , Pg.233 , Pg.234 ]




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