Steroid replacement therapy

Measure plasma cortisol after surgery to determine if the patient displays persistent hypercortisol ism (surgical treatment failure) or hypocortisolism (adrenal insufficiency requiring steroid replacement therapy). 

STEROID REPLACEMENT THERAPY Anticancer and Immunomodulating Drugs, Other immunomodulating drugs STRONTIUM RANELATE ... 

Romero MT, Cooper ML, Komisaruk BR, Bodnar RJ (1988) Gender-specific and gonadectomy-specific effects upon swim analgesia role of steroid replacement therapy. Physiol Behav 44 257-265... 

Robinson BG, Hales IB, Henniker AJ, et al. 1987. The effect of o- p -DDD on adrenal steroid replacement therapy requirements. Clin Enodcrinol 27 437- 444. 

Unlike other tissues, the vagina is greatly affected by steroid replacement therapy. Estrogen replacement therapy is often used to treat menopausal symptoms. The postmenopausal state of the vaginal epithelium, with its thinner epithelium and increased permeability, is an important consideration in drug delivery. The minimization of epithelial fluctuation will result in less fluctuation in absorption, affecting both systemic and local drug deliveries. 

The compound shown is diethylstilbestrol (DES) it has a number of therapeutic uses in estrogen replacement therapy DES is not a steroid but can adopt a shape that allows it to mimic estrogens such as estradiol (p 1100) and bind to the same receptor sites Construct molecular models of DES and estradiol that illustrate this similanty in molecular size shape and location of polar groups... 

The answer is e. (Katzung, p 672. Hardman, pp 1477—1978.) Fludrocortisone is a synthetic steroid compound that exhibits profound mineralo-corticoid activity and some glucocorticoid activity Electrolyte and water metabolisms are affected by the administration of this compound. Fludrocortisone promotes the reabsorption of Na and the urinary excretion of K and hydrogen ions in the collecting duct of the nephron. The drug is indicated for mineralocorticoid replacement therapy in primary" adrenal insufficiency... 

HRT (hormone replacement therapy) administration of estrogens to women or androgens to men who, due to menopause or age, have decreased levels of these plasma steroids. 

Synthetic steroids, especially estrogenic drugs, are used extensively in estrogen-replacement therapy and oral contraceptives, in veterinary medicine for growth enhancement, and in athletic performance enhancement. In general, large portions... 

I. Replacement therapy. The adrenal cortex (AC) produces the glucocorticoid cortisol (hydrocortisone) and the mine-ralocorticoid aldosterone. Both steroid hormones are vitally important in adaptation responses to stress situations, such as disease, trauma, or surgery. Cortisol secretion is stimulated by hypophyseal ACTH, aldosterone secretion by angiotensin 11 in particular (p. 124). In AC failure (primary AC insuffiency ... 

Corticosteroids do not heal illnesses, but they are widely used in various conditions when it is necessary to utilize their anti-inflammatory, immunosuppressant, and mineralo-corticoid properties. In addition, they are used in replacement therapy for patients who have adrenal insufficiency. Corticosteroids can be used in vital situations for asthma, severe allergic reactions, and transplant rejections. They are effective in noninfectious granulomatous diseases such as sarcoidosis, collagen vascular disease, rheumatoid arthritis, and leukemia. Steroids are used as lotions, ointments, etc. in treating a number of dermatological and ophthalmologic diseases. 

Androgenic steroids are used in medicine for replacement therapy in men with insufficient function of the male sex glands, for maturation arrest, impotency, climacteric, and other irregularities, and in women for breast and ovarian cancer and climacteric disorders. Like all steroid drugs, androgens are functionalized derivatives of cyclopentanophenan-threne. 

Pharmacology The naturally occurring adrenal cortical steroids have both anti-inflammatory (glucocorticoid) and salt-retaining (mineralocorticoid) properties. These compounds are used as replacement therapy in adrenocortical deficiency states and may be used for their anti-inflammatory effects. 

Replacement therapy Jranster from systemic steroid therapy may unmask allergic conditions previously suppressed. During withdrawal from oral steroids, some patients may experience withdrawal symptoms despite maintenance or improvement of respiratory function. 

For replacement of deficient aldosterone secretion, the fiuorinated steroid derivative fludrocortisone is used, usually in a dose of 100-200 pg per day. Replacement therapy is normally judged by monitoring blood pressure (lying and standing) and plasma electrolytes. 

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