Steroids replacement

Measure plasma cortisol after surgery to determine if the patient displays persistent hypercortisol ism (surgical treatment failure) or hypocortisolism (adrenal insufficiency requiring steroid replacement therapy). 

Rodriguez de Fonseca F, Cebeira M, Ramos JA, Martin M, Fernandez-Ruiz JJ. (1994). Cannabinoid receptors in rat brain areas sexual differences, fluctuations during estrous cycle, and changes after gonadectomy and sex steroid replacement. Life Sci. 54(3) 159-70. 

STEROID REPLACEMENT THERAPY Anticancer and Immunomodulating Drugs, Other immunomodulating drugs STRONTIUM RANELATE ... 

Romero MT, Cooper ML, Komisaruk BR, Bodnar RJ (1988) Gender-specific and gonadectomy-specific effects upon swim analgesia role of steroid replacement therapy. Physiol Behav 44 257-265... 

Robinson BG, Hales IB, Henniker AJ, et al. 1987. The effect of o- p -DDD on adrenal steroid replacement therapy requirements. Clin Enodcrinol 27 437- 444. 

Unlike other tissues, the vagina is greatly affected by steroid replacement therapy. Estrogen replacement therapy is often used to treat menopausal symptoms. The postmenopausal state of the vaginal epithelium, with its thinner epithelium and increased permeability, is an important consideration in drug delivery. The minimization of epithelial fluctuation will result in less fluctuation in absorption, affecting both systemic and local drug deliveries. 

Close monitoring of 24-hour urinary free cortisol levels and serum cortisol levels are essential to monitor for adrenal insufficiency. Steroid secretion should be monitored with all of these drugs and steroid replacement given as needed. Whatever the choice, pharmacologic therapy in pituitary-dependent disease is mainly centered... 

TABLE 74—5. Alternative Steroid Replacement Regimens in the Adrenal Adenoma Patient... 

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