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Statistical analysis quality management controls using

Many of the quality improvement goals for implementation of PAT in the pharmaceutical industry have been achieved by companies in other industries, such as automobile production and consumer electronics, as a direct result of adopting principles of quality management. The lineage of modern quality management can be traced to the work of Walter Shewhart, a statistician for Bell Laboratories in the mid-1920s [17]. His observation that statistical analysis of the dimensions of industrial products over time could be used to control the quality of production laid the foundation for modern control charts. Shewhart is considered to be the father of statistical process control (SPC) his work provides the first evidence of the transition from product quality (by inspection) to the concept of quality processes [18,19]. [Pg.316]

Depending on the chosen approach (see Section 3.1) service quality can be measured from the customer s and the service provider s point of view. Measuring from the service provider s point of view involves gathering data that are internally available, such as performance measures or quality cost (Eversheim 1997). They can be analyzed using well-known methods from quality management in manufacturing processes, such as statistical process control (Gogoll 1996). In addition, service quality can be assessed indirectly by an overall analysis of the quality system, which is done by a... [Pg.640]

A principal components multivariate statistical approach (SIMCA) was evaluated and applied to interpretation of isomer specific analysis of polychlorinated biphenyls (PCBs) using both a microcomputer and a main frame computer. Capillary column gas chromatography was employed for separation and detection of 69 individual PCB isomers. Computer programs were written in AMSII MUMPS to provide a laboratory data base for data manipulation. This data base greatly assisted the analysts in calculating isomer concentrations and data management. Applications of SIMCA for quality control, classification, and estimation of the composition of multi-Aroclor mixtures are described for characterization and study of complex environmental residues. [Pg.195]


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