Staphylococcus aureus biological properties

Characterization of Anti-Infective Biological Activity. Acute sepsis models utilizing either Escherichia coli or Staphylococcus aureus intraperitoneal challenge were developed to evaluate the anti-infective properties of PGG in mice. 

Protein A is a specific protein isolated from the cell wall of Staphylococcus aureus whose characteristic property is the ability to react and to form precipitates with a variety of IgG molecules from several species. This interaction is reminia nt of the formation of antigen-antibody complexes, and has been used to study different aspects of immune response as well as cell surface structure and function For easier detection, Protein A is covalently coupled to fluorescein isothiocyanate (FITC). The commercial preparations of FITC-Protein A contain an avarage of 6 FITC substituent groups per molecule of protein. Such a degree of labeling does not affect the biological properties of the native protein. 

Lee PK, Kreiswirth BN, Deringer JR, et al. Nucleotide sequences and biologic properties of toxic shock syndrome toxin 1 from ovine- and bovine-associated Staphylococcus aureus. J Infect Dis. 1992 165 1056-1063. 

The simplest form of a Free Wilson analysis is presented in eq. 192 [22], which describes the antibacterial activities of phenol and isomeric chlorophenols (51, R = H, Cl one to five chlorine atoms) vs. Staphylococcus aureus at least the linearity of the structure-activity relationship can be derived from eq. 192 on the other hand, although most probably lipophilicity is responsible for the variance in the biological activities, no Hansch equation can be derived, because each other physicochemical property of the chlorine atom will give identical results. 

Benzoxazole derivatives have many biological activities such as anti-inflammatory, antiviral, antibiotic, anticancer, and so on. Anand et al. (2011) reported SSA-catalyzed microwave-assisted rapid synthesis of substituted benzoxazole derivatives and studied their antimicrobial properties on various strains such as Staphylococcus aureus, Escherichia coli, Candida glabrata, and so on (Scheme 5.30). 

The cell distribution of 3-amino-4-hydroxymethyl acridine derivatives 70 (Scheme 25), which has the N3—C4—16 substitution pattern, was studied by real-time fluorescence microscopy and SIMS structured illumination microscopy). The latter method required the introduction of an iodine atom at position 6 of the acridine which influences the Upophihcity but does not modify significantly the biological properties such as IC50 and subcellular localization (2009EJMC4758). A co-polymer 71 consisting of water-soluble maleic anhydride-containing poly[maleic anhydride-u/i-acrylic acid] (poly(MA-alt-AA) or MAAA) copolymer was modified with acriflavine (AF) which displayed antibacterial activity on EHEC and Staphylococcus aureus (2014MI2903). 

Some of the biological properties of the actinomycins produced by 5. antibioticus are presented in Table 1. It is evident that actinomycin IV is twice as active as actinomycin II and two and one half times as active as actinomycin III against Staphylococcus aureus and Bacillus subtilis. When the toxicity of these compounds was determined in mice, intraperitoneally, the LDgg was actinomycin II, 6 to 8 mg/kg actinomycin III, 1.5 to 3.0 mg/kg and actinomycin IV, 1.0 mg/kg. 

Lee, P.K., Kreiswirth, B.N., Deringer, J.R., Projan, S.J., Eisner, W., Smith, B.L., Carlson, E., Novick, R.P, and Schlievert, P.M. 1992. Nucleotide sequences and biological properties of toxic shock syndrome toxin 1 from ovine- and bovine-associated Staphylococcus aureus. J. Infect. Dis. 165 1056-1063. 

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