Spontaneous improvement

To allow for repeated assessment of symptom severity and stability, i.e. to identify and take out patients with clear placebo response or early spontaneous improvements. 

Whereas the sequence is strongly suggestive of a beneficial effect with higher CBZ levels, we cannot rule out the possibility of a spontaneous improvement due to her history of rapid cycling. 

Work has been done to find whether the very expensive treatment of wines with artificial cold could be advantageously replaced by the addition of inhibitors of the crystallization process of tartrate salts such as metatartaric acid, yeast mannopro-teins or carboxymethylcellulose (CMC). Such inhibitors indeed increase the width of the supersaturation field of both KHT and TCa in the wine, thus delaying tartrate salt precipitation in the bottle. Metatartaric acid is currently the product most widely used for this purpose, though its efficacy is low as this compound does not remain stable over time. Yeast mannoproteins possess stabilizing properties, which result in the spontaneous improvement of protein and tartaric salt stability, as can be... 

Up to now, there is no satisfactory drug therapy for HPS available. Spontaneous improvement of HPS after recovery from an underlying liver disease has been reported. Often HPS has deteriorated despite stable liver function. Improvements in HPS with the help of various substances, for which a certain therapeutic effect was considered plausible, were only achieved in individual cases and for just a limited time. (4, 28, 45)... 

Only an efficient antiyiral immune reaction can eliminate the hepatitis C virus. In cases of acute HCV infection, minimal (endogenous) interferon-a values are detectable in the serum, i.e. the virus effects a poor interferon induction in the organism. The CD8+ and CD4 T lymphocytes appear to be mainly responsible for virus elimination. The problems of HCV infection lie in the fact that the patient has virtually no chance of spontaneous improvement or even healing with a chronic course of disease, i.e. there is practically no self-limiting factor in a disease process that has become chronic. 

There is no specific treatment for mercury poisoning of the kidneys but removal of the source of the metal is important. This maneuver may result in spontaneous improvement in 50% of cases [25]. Brown, in a study from Malawi, described the failure to improve in 2 out of 6 patients with membranous nephropathy who were known to have used skin creams [28]. This occurred despite removal from exposure to the mercury as well as the administration of steroids. 

DM DA DC Local irritant, induces vomiting. Wear mask in spite of symptoms-the mask should be lifted in the event of vomiting. Spontaneous improvement. No effects. 

CN CA Local irritant. Spontaneous improvement. Analgesic eye and nose drops if necessary. No effects. 

Once TD has developed, spontaneous improvement occurs in 30-50% of cases within 2 years after discontinuation of the APD. The main goal in treating TD is to desensitize the hyperactive dopaminergic receptors or to counterbalance their activities. Because prolonged and complete drug withdrawal is often difficult, total or partial substitution with SCAs (especially clozapine) is proposed as the first-line strategy for patients who have to continue APDs. It is assumed that SCAs,... 

Most patients with hepatic sarcoidosis do not require treatment (81). Although treatment with corticosteroids can improve liver function tests in approximately half of asymptomatic patients, three-fourths of such patients who are not treated eventually undergo spontaneous improvement in liver function tests and the rest remain stable (59). Furthermore, evidence suggests that corticosteroid treatment of hepatic sarcoidosis promotes relapse (87). On the basis of these data, therapy for hepatic sarcoidosis is not indicated in asymptomatic patients with Uver function test elevations. Such patients should be followed with serial Uver function tests, although it is rare for them to develop hepatic failure (59). 

Corticosteroids are the current standard treatment of OP (2,6,9,11,16-19), although spontaneous improvement has occasionally been reported (2). Clinical improvement is usually observed within two days after treatment onset. At imaging, pulmonary infiltrates usually markedly improve within a few days and disappear completely within a few weeks. The speed of response to corticosteroids in OP is slower than in chronic idiopathic eosinophilic pneumonia, but faster than in NSIP and roughly comparable to hypersensitivity pneumonitis. The spectacular and reproducible response to corticosteroids can further be considered as an additional diagnostic feature of the clinical syndrome of OP, and if this response is poor, the initial diagnosis should be reconsidered. Removal of the causing agent should be done in secondary OP, whenever possible. 

A review on agranulocytosis related to levamisole noted the spontaneous improvement in cell counts without the use of bone marrow stimulants (e.g. granulocyte colony-stimulating factor) within 5-10 days and argued for a conservative diagnostic and therapeutic approach to leucopenia if it is encountered in the setting of levamisole exposure [26. ... 

Gastrointestinal - eosinophilic gastroenteritis A 54-year-old male treated with pegylated IFNa-2a for chronic hepatitis C infection showed abdominal distension and diarrhoea 28 weeks after initiation of therapy. Elevation of the eosinophil count in blood and ascites and eosinophil infiltration observed in gastrointestinal histopathology led to a diagnosis of eosinophilic enteritis but therapy was not initiated due to spontaneous improvement in both the eosinophil count and abdominal symptoms. This appears to be the first case report of eosinophilic enteritis induced by IFN therapy [45 ]. 

A spontaneous improvement could occur in the neighborhood of liquid helium temperatures due to the reduced heat capacity of copper relative to its thermal conductivity in this region. 

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