Somatotropin receptor

Zorbtive (somatotropin) (US) Approval 2003 Recombinant human somatotropin receptors on a variety of cell types including myocytes, hepatocytes, adipocytes, lymphocytes, and hematopoietic cells. Short bowel syndrome Fertilitv and earlv embrvonic development unclear Developmental rats, rabbits Prenatal and postnatal development unclear Genetic toxicolosv none Carcinogenicitv none... 

Reported applications of DSS include crosslinking the A and B subunits of ricin (Montesano et al., 1982), studying human somatotropin and the components of the lactogenic-binding sites of rat liver (Caamano et al., 1983), crosslinking CSF-1 to its cell-surface receptor (Morgan... 

Bruns, C Lewis, I., Briner, U., Meno-Tetang, G and Weckbecker, G. (2002) SOM230 a novel somatostatin petidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile. Eur. J. Endocrin. 146,707-716. 

Somatotropin release inhibiting factor) receptor (SRIF-R) ... 

SRIF-R, somatostatin (somatotropin release inhibiting factor) receptor SRP, signal recognition particle S-S, disulphide... 

These JAK/STAT-coupled receptors concern the effects of cytokines the growth hormone somatotropin (GH), erythropoietin (EPO), prolactin (PRL), granulocyte-colony-stimulating-factor (G-CSF), granulocyte and macrophage-colony-stimulating-factor (GM-CSF), leptin, thrombopoi-etin, interferons a, 3 and % and interleukins 2, 3,4, 5, 6, 7, 9,10 and 15. 

Somatotropin Growth hormone a 191-amino acid polypeptide hormone that is synthesized and secreted from the somatotroph cells of the anterior pituitary. It acts primarily on hepatocytes, although muscle and adipose cells also have receptors for growth hormone. 

These include the receptors for erythropoietin, somatotropin, and interferons. Their receptors... 

Reactant ion peak 1347 Rebetron 17 Rebif 17, 467, 1404 RecDNA somatotropin 477 Receptor tyrosine kinase (RTK) 639 RECIST criteria 1259... 

These include the receptors for erythropoietin, somatotropin, and interferons. Their receptors are membrane spanning and on activation can activate a distinctive set of cytoplasmic tyrosine kinases (Janus kinases [JAKs]). JAKs phosphory-late signal transducers and activators of transcription (STAT) molecules. STATs dimerize and then dissociate, cross the nuclear membrane, and modulate gene transcription. 

The abundant IGF-I (somatomedin C), a 70-residue single-chain basic peptide with a sequence and three-dimensional structure homologous to that of proinsu-lin,206.207 jg considered a major mediator of the action of fhe pifuitary growth hormone (GH, somatotropin). Studies in cell culture suggest that GH may induce differentiation of cells, and that IGF-I may then cause a rapid proliferation of the newly differentiated cells. The homologous 67-residue IGF-II may have a similar function in fetal development. TTie cell surface receptor for IGF-I is similar to the insulin receptor, but IGF-II receptor is structurally different. It is a monomeric 250-kDa protein and although it is a substrate for a fyrosine kinase, it has no kinase activity of its... 

Bruns C, Lewis i, Briner U, et ai. SOM230 a novei somatostatin peptidomimetic with broad somatotropin reiease inhibiting factor (SRiF) receptor binding and a unique antisecretory profiie. Eur J Endocrinoi 2002 146 707-716. 

Somatotropin, another example, has at least two binding proteins in plasma [16]. This protein binding substantially reduces somatotropin elimination with a tenfold smaller clearance of total compared to free somatotropin, and also decreases its activity via reduction of receptor interactions. 

---