Methacrylate hydroxypropyl

Selected physical properties of various methacrylate esters, amides, and derivatives are given in Tables 1—4. Tables 3 and 4 describe more commercially available methacrylic acid derivatives. A2eotrope data for MMA are shown in Table 5 (8). The solubiUty of MMA in water at 25°C is 1.5%. Water solubiUty of longer alkyl methacrylates ranges from slight to insoluble. Some functionalized esters such as 2-dimethylaniinoethyl methacrylate are miscible and/or hydrolyze. The solubiUty of 2-hydroxypropyl methacrylate in water at 25°C is 13%. Vapor—Hquid equiUbrium (VLE) data have been pubHshed on methanol, methyl methacrylate, and methacrylic acid pairs (9), as have solubiUty data for this ternary system (10). VLE data are also available for methyl methacrylate, methacrylic acid, methyl a-hydroxyisobutyrate, methanol, and water, which are the critical components obtained in the commercially important acetone cyanohydrin route to methyl methacrylate (11). 

The first reactions were carried out at room temperature in devices fabricated from a thiolene resin cured between two glass slides. 2-Hydroxypropyl methacrylate (HPMA) was polymerized by ATRP, and reaction kinetics similar to those obtained in a traditional batch reaction were obtained by adjusting the total flow rate of the fluid through the channel and treating the residence time in the channel as the reaction time (Fig. 21b,c) [102]. 

Recently, further synthetic polymers have been proposed as plasma substitutes. Thus, Kopecek and Bazilova (56) examined poly[N-(2-hydroxypropyl)methacryl-amide] [22]. 

Fourier transform infrared spectroscopy glycidyl methacrylate group transfer polymerization 2-hydroxyethyl methacrylate hydrophobic-lipophilic-balance hydroxypropylcellulose 2-hydroxypropyl methacrylate initiator concentration decomposition rate constant propagation rate constant termination rate constant... 

Investigations on the spacer function and the cleavabflity of the substrate from water-soluble copolymeric enzymes based on poly[N-(2-hydroxypropyl)methacryl-amide] were carried out by Kopecek and coworkers These studies reveal that there is no simple relationship between the length of the spacer and the cleava-bility of the substrate. It has also been observed that the length and the type of the spacer allows the kinetics of the cleavage to be controlled. 

Poly(vinyl cyclopentane) Poly(2-hydroxypropyl methacrylate) Poly(p-methoxymethyl styrene)... 

HYDROXYPROPYL METHACRYLATE, 2-HYDROXYPROPYL METHACRYLATE, or p-HYDROXYPROPYL METHACRYLATE (923-26-2) Forms explosive mixture with air (flash point 250°F/121°C). Strong oxidizers may cause fire and explosions. May polymerize when hot or when exposed to UV light or free-radical catalysts. 

HPMA 2-hydroxypropyl methacrylate ku rate constant for reaction with chain transfer agent... 

Kopecek, J., Rejmanova, P., Duncan, R. and Lloyd, J.B. (1985) Controlled release of drug model from N-(2-hydroxypropyl)methacryl-amide copolymers. Ann. NY Acad. Sci. 446 93-104. 

Shiah J-G, Dvorak M, Kopeckova P, Sun Y, Peterson CM, Kopecek J. Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacryl unide copolymer-doxorubicin conjugates in nude mice. Eur J Cancer 2001 37 131-139. 

AC1 Acikses, A., Kaya, I., Sezek, U., and Kirilrrris, C., Syrrthesis, characterization and thermodynamic properties of poly(3-mesityl-2-hydroxypropyl methacrylate-co-A-vinyl-2-pyrrolidone). Polymer, 46, 11322, 2005. 

Poly [A -(2-hydroxypropyl)meth-aciylamide monolactate-co-A -(2-hydroxypropyl)methacryl-amide dilactate] ... 

A photopolymerized microfluidic device consisting of two inlets, active mixing chamber containing a magnetic stir bar, a single reaction chaimel (500 pm x 600 pm), and one outlet has been used for ATRP reaction of 2-hydroxypropyl methacrylate (HPMA) initiated by methyl 2-bromopropionate (Fig. 23) [205]. The molecular weight can be controlled by changing the residence time at the different flow rates (Table 5). The kinetics and polymer properties are similar to those for the batch reactions reported in the literature [206]. Furthermore, a block copolymer poly... 

Fig. 23 Microfluidic device for the s)oithesis of poly(2-hydroxypropyl methacrylate) (PHPMA) using a MBP initiator...

Fig. 24 Microfluidic device for the synthesis of poly(ethylene oxide-Wocfc-2-hydroxypropyl methacrylate) (PEO-fc-PHPMA) using a PEO macroinitiator...

Save M, Weaver JVM, Armes SP et al (2002) Atom transfer radical polymerization of hydroxy-functional methacrylates at ambient temperature comparison of glycerol monomethacrylate with 2-hydroxypropyl methacrylate. Macromolecules 35 1152-1159... 

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