Best practice analysis

Best Practice Analysis characterize the management practices and software solutions that result in best-in-class performance. 

Note that the lamina failure criterion was not mentioned explicitly in the discussion of Figure 4-36. The entire procedure for strength analysis is independent of the actual lamina failure criterion, but the results of the procedure, the maximum loads and deformations, do depend on the specific lamina failure criterion. Also, the load-deformation behavior is piecewise linear because of the restriction to linear elastic behavior of each lamina. The laminate behavior would be piecewise nonlinear if the laminae behaved in a nonlinear elastic manner. At any rate, the overall behavior of the laminate is nonlinear if one or more laminae fail prior to gross failure of the laminate. In Section 2.9, the Tsai-Hill lamina failure criterion was determined to be the best practical representation of failure... 

Best practices in the generation and analysis of residues in crop, food and feed... 

Best practices in the analysis of residues in environmental samples groundwater and soil-water monitoring procedures... 

Another important quality measure is the analysis of the field-fortified samples. The field-fortified samples have been handled, shipped and stored in the same manner as the treated samples. Any loss of analyte in the field-fortified samples will be used to correct residue levels of the field treated samples. It is best practice to keep the storage interval as short as possible to minimize losses. The acceptable storage time will vary according to the stability of each compound in aqueous solution. A good guideline is to analyze the samples within 30 days of sampling. 

EURACHEM Guidance Document No. CITAC Guide 2 QA Best Practice for Research and Development and Nonroutine Analysis, Working Draft 40, April 1997. Available from the EURACHEM Secretariat, Dept of Chemistry and Biochemistry, University of Lisbon, Portugal. 

Nowadays, best practice is to combine both modelling and analysis of chemicals for an appropriate assessment of chemical exposure in environmental scenarios. Future research activities should focus on the development of reliable analytical methods at trace level concentrations. 

To improve the ability to establish best practice with respect to manure use and prevention of pathogen transfer (especially on farms which are converting to organic farm management), a hazard analysis critical control point (HACCP)-based quality assurance system has been proposed (Haward and Leifert, 1999). This proposed four main critical control points (CCPs) (see Table 19.4). 

Each screening center has medicinal and synthetic chemistry expertise in order to optimize hits identified from HTS campaigns and develop them into chemical probes. Specific capabilities vary, however typical strategies employed include parallel synthesis, computational and informatics analysis, and analytical capabilities such as LC/MS techniques. The structures of novel compounds that are prepared, their synthetic protocols, analytical data and biological data are all available, and samples of final probes developed are deposited into the MLSMR. A Working Group comprised of chemists from each center meets regularly to share information, best practices, and insure optimal use of resources. 

In in vivo studies, an important issue is the quality of ECG recordings and the methods used for the analysis. A few years ago, a survey reported on the practice in the pharmaceutical industry to assess the potential for QT prolongation and concluded that the majority view in the industry is not necessarily best practice [153]. After this publication, a lot of work has been done to improve the performance of in vivo models, although it should be acknowledged that their cost (together with some ethical considerations on the rational use of animals) makes them unsuitable for large-scale screening. 

This chapter reviews the myriad SP techniques used in pharmaceutical analysis and focuses discussion on those commonly used for pharmaceutical products, such as grinding, mixing, sonication, dilution and filtration. The best practices and technical judgments used in developing SP procedures are illustrated with several case studies of assays and impurity testing. 

To be effective the investigation must apply an approach which is based on basic incident causation theories and use tested data analysis techniques. Investigating incidents to determine root causes and make recommendations can be as much an art as a science. Within the industry, best practices in incident investigation have evolved substantially in the last 20 years. This chapter provides a brief overview of some of the more relevant causation theories. 

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