Sodium hydrogen sulfate, with phosphate

Transfer the residue prepared as in Section 6.1.1 into a 300-nL separatory funnel with 25 mL of phosphate buffer solution (0.1 M, pH 7.4). Add 10 mL of saturated aqueous sodium chloride and 50 mL of 0.5 M sodium hydrogen carbonate to the funnel and shake the funnel vigorously for 1 min. Add 70 mL of ethyl acetate to wash the aqueous layer to the funnel, shake, separate, and discard the ethyl acetate layer. Repeat this extraction procedure three times. Add 2 mL of phosphoric acid and 20 mL of an acetate buffer solution (0.1 M, pH 4) to the aqueous layer and extract the mixmre with 50 mL of ethyl acetate three times. Combine the extracts and filter into a 500-mL round-bottom flask through 60 g of anhydrous sodium sulfate supported by a plug of cotton wool in a funnel. Concentrate the filtrate to dryness under reduced pressure. 

Various salts, sodium, potassium, hydrogen sulfate, phosphate, and chloride, of RS-82856 were prepared with the preformulation parameters solubility, hygroscopicity, and intrinsic dissolution rate were also determined. The hydrogen sulfate salt was chosen as the candidate because of the twofold increase in bioavailabity when compared with the parent compound. ... 

Mobile phase MeCN buffer 30 70, pH adjusted to 7.0 with NaOH (Buffer was 20 mM sodium phosphate and 5 mM tetrabutylammonium hydrogen sulfate.)... 

Mobile phase MeCN buffer 24 76 (Buffer was 50 mM potassium hydrogen phosphate containing 1 mM sodium dodecyl sulfate adjusted to pH 2.5 with orthophosphoric acid.)... 

EthyM-hexanol ester with diphenyl phosphate. See Diphenyl octyl phosphate 2-Ethyl-1-hexanol hydrogen phosphate. See,Di (2-ethylhexyl) phosphate 2-Ethyl-1-hexanol, hydrogen sulfate, sodium salt. See Sodium 2-ethylhexyl sulfate 2-Ethylhexanol phosphate. See Trioctyl phosphate 2-Ethylhexyl phosphate 2-Ethyl-1-hexanol phosphate 2-Ethylhexanol, phosphate triester. See Trioctyl phosphate 2-Ethyl-1-hexanol silicate. See Tetrakis (2-ethylhexoxy) silane... 

Sodium lauryl sulfate (1 g) and sodium hydrogen phosphate (100 mg) were dissolved in 80 rrrL of water taken in a three-necked round-bottom flask equipped with a mechanical stirrer, a condenser, and a inlet to rrraintain the inert rritrogen atmosphere. The flask was immersed in an oil bath with a thermostatic corrtrol to maintain the desired temperature accurate to 1 °C. The solution was stirred at 800 rpm speed until it became clear and 100 mg of potassium per sulfate was added. Required amourrt of monomers, cross-lirrking agent, NNMBA and Acebutolol hy-... 

Mobile phase MeCNilO mM disodimn hydrogen phosphate containing 5 mM sodium dodecyl sulfate 34 66, adjusted to pH 7.1 with orthophosphoric acid Flow rate 1 Injection volume 25 Detector UV 226... 

Hexadecanoi, hydrogen suitete, sodium saH. See Sodium cetyl sulfate 1-Hexadecanol lactate. See Cetyl lactate 1-Hexadecanol, phosphate (3 1). See Tricetyl phosphate 1-Hexadecanol, phosphate, compd. with 2,2 -iminobis [ethanol] (1 1). See DEA-cetyl phosphate... 

Tridecanol 1-Tridecanol n-Tridecanol. See Tridecyl alcohol Tridecanol condensed with 6 moles ethylene oxide. See Trideceth-6 1-Tridecanol, dihydrogen phosphate. See Tridecyl phosphate 1-Tridecanol, hydrogen sulfate, sodium salt. See Sodium tridecyl sulfate Tridecanol stearate. See Tridecyl stearate Trideceth... 

Costantino et al. [103] reported the direct aza-Diels-Alder reaction between 2-cyclohexen-l-one and benzaldimines in water, catalyzed by layered a-zirconium hydrogen phosphate (a-ZrP) in the presence of sodium dodecyl sulfate (SDS) at 30 ° C (Table 6.2). The yield of the product was good, and the reaction was faster and the exo-diastereoselectivity was higher than when an organic solvent was used. A Cr(III)(salen)Cl catalyst embedded into a self-assembled supramolecular aggregate displays substrate selectivity with an up to 3.5 fold increase in activity in favor of longer over shorter dienophiles in the reaction with cyclopentadiene under aqueous micellar conditions [104]. 

The gels precipitated as described above are not useful in ion-exchange systems because their fine size impedes fluid flow and allows particulate entrainment. Controlled larger-sized particles of zirconium phosphate are obtained by first producing the desired particle size zirconium hydrous oxide by sol—gel techniques or by controlled precipitation of zirconium basic sulfate. These active, very slightly soluble compounds are then slurried in phosphoric acid to produce zirconium bis (monohydrogen phosphate) and subsequently sodium zirconium hydrogen phosphate pentahydrate with the desired hydrauhc characteristics (213,214). 

Alcoholysis of the chloride on the plant scale was effected at 40°C (with brine cooling) by adding portions to the alcohol alternately with finely crystalline disodium phosphate to neutralise the hydrogen chloride produced. On one occasion, use of coarsely crystalline sodium phosphate (of low surface area) reduced the rate of neutralisation, the mixture became acid, and a runaway exotherm to 170°C developed leading to eruption of vessel contents. On another occasion, accidental addition of sodium sulfate instead of phosphate led to a similar situation beginning to develop, but an automatic pH alarm allowed remedial measures to be instituted successfully. See other neutralisation incidents... 

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