Sodium acetate sulfite

To the filtrate obtained, there are then added about 0.2 gram of sodium hydrosulfite or sodium sulfite and 15.0 grams of anhydrous sodium acetate in about 27 grams of acetic anhydride at 40°C. The reaction mixture formed is cooled to 8° to 10°C with stirring and held at this temperature for 60 minutes. A crystalline precipitate of about 27 grams of N-acetyl-p-aminophenol is obtained melting at 169°-171°C. This is equivalent to a yield of 85%. 

Reagents required for the conventional method include sodium hydrogen sulfite (Sigma-Aldrich, cat. no. 243973), hydroquinone (Sigma), NaOH (3M), mineral oil. Wizard DNA Cleanup system (Promega), isopropanol, ammonium acetate (lOAf), glycogen, and ethyl alcohol. 

It was prepd by the action of sodium sulfite on 3-nitronaphthalene-l-diazoacetate, previously obtd by diazotizing 3-nitro-l-naphthyl amine and treating the diazonium chloride with aq sodium acetate (Ref 5)... 

C 2-Bromo-4-methylbenzaldehyde A 3-1. three-necked flask is equipped with an efficient stirrer, a dropping funnel (Note 2), and a thermometer. The aqueous 10% formaldoxime prepared in step A is placed in the flask, and to it are added 6 5 g (0.026 mole) of hydrated cupric sulfate, 1.0 g. (0 0079 mole) of sodium sulfite, and a solution of 160 g of hydrated sodium acetate in 180 ml. of water The solution is maintained at 10-15° by means of a cold-water bath and stirred vigorously. The neutral diazonium salt solution prepared in step B is slowly introduced below the surface of the formaldoxime solution (Notes 3 and 4). After the addition of the diazonium salt solution is complete, the stirring is continued for an additional hour and then the mixture is treated with 230 ml. of concentrated hydrochloric acid. The stirrer and the dropping funnel are replaced by stoppers, and the mixture is gently heated under reflux for 2 hours The flask is set up for steam distillation, and the reaction product is steam-distilled. The distillate is saturated with sodium chloride, extracted with three 150-ml portions of ether, and the ethereal extracts are washed successively with three 20-ml portions of a saturated sodium chloride solution, three 20-ml. portions of an aqueous 10% sodium bicarbonate solution, and again with three 20-ml portions of a saturated sodium chloride solution. 

Formation of 2-propyl-5-nitrobenzothiazole on reduction of 2,4-dinitro-butylth-iobenzene with sodium poly sulfite or trimethylphosphite has been observed [599], para-To] uenesul fonate 2,5-dimethyl-7-nitrobenzothiazole was obtained under the action of excess thioacetic acid on AK4-methyl-2,6-dinitrophenyl)pyridinium [600], The reaction involves the formation of 4-methyl-2,6-dinitrothiophenol acetate in which, under experimental conditions, one of the nitro groups is reduced to an amino group with subsequent cyclization, as shown in Scheme 2.109. 

Liquors from Neutral Semichemical Pulping and from Kraft Pulping. In making neutral sulfite semichemical pulp, the black liquors may have about 10 parts of water to 1 part of total solids, of which about one-third is sodium acetate and sodium formate. After evaporation to about 1 part solids to 1 part water, sulfuric acid is added to the concentrate to free the acetic and formic acids. When the concentrate is extracted with acetone, the mixed acids are obtained, the acetone is separated for recycle, and the acids are concentrated and refined. The raffinate is stripped and is passed to the usual furnace to be burned for recovery of the inorganic salt values. This process gives a smelt of sodium sulfate, which may be used in the kraft process as chemical makeup. The loss of the fuel value of the acetic and formic acids is practically negligible. 

The acid-sensitive amino phenols can be obtained by the reduction of nitro phenols with sodium sulfide or sodium hydrogen sulfite or by treatment of the f-tolylsulfonic esters with iron and acetic acid. Also, hydrogenation over Raney nickel at 100° gives excellent results. ... 

The reduction of diazonium salts by sodium sulfite forms monosub-stituted arylhydrazines. An improved procedure for the synthesis of phenylhydrazine in 84% yield is typical. Arylhydrazine salts substituted in the nucleus with halo," ether, carboxyl, or nitro groups have been prepared. The free bases are liberated from the salts by the action of aqueous sodium hydroxide or sodium acetate. 

Chlorination of 2-amino-3-methoxycarbonylpyrazine in aqueous acetic acid gave 5-chloro-2-chloroamino-3-methoxycarbonylpyrazine (47), which reacts with sodium hydrogen sulfite to give 2-amino-5-chloro-3-methoxycarbonylpyrazine (150,378a, 778, 779, 781-787). 

Tellurophene and substituted tellurophenes react with bromine to give Te,Te-dibromides, as do dialkyl and diaryl telluriums. Tetrachlorotellurophene and chlorine combined to produce tetrachlorotellurophene Te.Te-dichloride in quantitative yield". The corresponding reactions with iodine have not been investigated. The dibromides are reduced to tellurophenes by aqueous sodium hydrogen sulfite or zinc powder in glacial acetic acid. ... 

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