Sodium acetate chloride

Sodium (acetate, chloride, phosphate) Potassium (acetate, chloride, phosphate) Magnesium sulfate Calcium gluconate... 

For complete acetylation of polyhydric compounds, such as glucose (p. 141) and mannitol (p. I42), even undiluted acetic anhydride is insufficient, and a catalyst must also be employed. In such cases, the addition of zinc chloride or anhydrous sodium acetate to the acetic anhydride usually induces complete acetylation. ... 

Required Anhydrous sodium acetate, 21 g. acetyl chloride, IS ml. 

Carry out this preparation precisely as described for the a-compound, but instead of zinc chloride add 2 5 g. of anhydrous powdered sodium acetate (preparation, p. 116) to the acetic anhydride. When this mixture has been heated on the water-bath for 5 minutes, and the greater part of the acetate has dissolved, add the 5 g. of powdered glucose. After heating for I hour, pour into cold water as before. The viscous oil crystallises more readily than that obtained in the preparation of the a-compound. Filter the solid material at the pump, breaking up any lumps as before, wash thoroughly with water and drain. (Yield of crude product, io o-io 5 g.). Recrystallise from rectified spirit until the pure -pentacetylglucose is obtained as colourless crystals, m.p- 130-131° again two recrystallisations are usually sufficient for this purpose. 

Mannitol, CH,0H(CH0Hi4CH40H, is a hexahydric alcohol obtained by the reduction of mannose. Since ring formation does not occur in mannitol, the hexacetyl derivative can exist in only one form, and therefore either zinc chloride or sodium acetate can be used as a catalyst for the acetylation. 

Acetyl chloride Sodium acetate Acetic anhydride... 

An equivalent result may be obtained by treating excess of sodium acetate with phosphorus oxychloride acetyl chloride is an intermediate product and the final result is ... 

J The hexa.acetyl derivative, m.p. 121°, may be prepared as follows. Boil under reflux 1 part of mannitol with 5 parts by weight of acetic anhydride and 1 part of anhydrous sodium acetate or with a little anhydrous zinc chloride for 15-20 minutes, pour into excess of water, stir the mixture until the oil has solidifled, and then recrystallise from methylated spirit. 

Acetates. Complete acetylation of all the hydroxyl groups is desirable in order to avoid mixtures. In some cases, the completely acetylated sugars may be obtained in the a- and p-forms depending upon the catalyst, e.g., zinc chloride or sodium acetate, that is employed in the acetylation. The experimental details for acetylation may be easily adapted from those already given for a- and p-glucose penta-acetates (Section 111,137). 

Attention has previously (see Diazonium Sails) been drawn to the fact that unless an excess of hydrochloric (or mineral) acid is used in the diazotisation process, coupling occurs between the diazonium salt and the amine to give diazoamino compounds. Thus phenyldiazonium chloride and aniline yield diazoaminobenzene. This substance may be conveniently prepared by dissolving two equivalents of aniline in three equivalents of hydrochloric acid, and adding one equivalent of sodium nitrite in aqueous solution followed by two equivalents of sodium acetate ... 

Unsymmetrical diaryls may be prepared by treating an aryl diazonium salt solution with sodium hydroxide or sodium acetate in the presence of a liquid aromatic compound. Thus 2-chlorodiphenyl is readily formed from o-chloro phenyl diazonium chloride and sodium hydroxide solution (or sodium acetate solution) in the presence of benzene ... 

The important chemical properties of acetyl chloride, CH COCl, were described ia the 1850s (10). Acetyl chloride was prepared by distilling a mixture of anhydrous sodium acetate [127-09-3J, C2H202Na, and phosphorous oxychloride [10025-87-3] POCl, and used it to interact with acetic acid yielding acetic anhydride. Acetyl chloride s violent reaction with water has been used to model Hquid-phase reactions. 

Lente insulin is an almost colorless suspension of a mixture of characteristic crystals predominandy 10—40 p.m in maximum dimension, and many particles that have no uniform shape and do not exceed 2 p.m in maximum dimension. On a wt/vol basis, it contains 0.15—0.17% sodium acetate, 0.65—0.75% sodium chloride, 0.09—0.11% methylparaben, and 0.20—0.25 mg of 2inc of which 40—65% is in the supernatant Hquid. Its pH is 7.1—7.5. 

Complexing agents, which act as buffers to help control the pH and maintain control over the free metal—salt ions available to the solution and hence the ion concentration, include citric acid, sodium citrate, and sodium acetate potassium tartrate ammonium chloride. Stabilizers, which act as catalytic inhibitors that retard the spontaneous decomposition of the bath, include fluoride compounds thiourea, sodium cyanide, and urea. Stabilizers are typically not present in amounts exceeding 10 ppm. The pH of the bath is adjusted. 

The production of triphenyl tin hydroxide [76-87-9] and triphenyl tin acetate [900-95-8] start with triphenyl tin chloride, which is prepared by the Kocheshkov redistribution reaction from tetraphenyltin and tin tetrachloride. The hydroxide is prepared from the chloride by hydrolysis with aqueous sodium hydroxide. The acetate can be made directiy from the chloride using sodium acetate or from the hydroxide by neutrali2ation with a stoichiometric quantity of acetic acid. 

Treatment of benzal chloride [98-87-3] with anhydrous sodium acetate at 180—200°C provides another economically attractive route to cinnamic... 

However, this method is appHed only when esterification cannot be effected by the usual acid—alcohol reaction because of the higher cost of the anhydrides. The production of cellulose acetate (see Fibers, cellulose esters), phenyl acetate (used in acetaminophen production), and aspirin (acetylsahcyhc acid) (see Salicylic acid) are examples of the large-scale use of acetic anhydride. The speed of acylation is greatiy increased by the use of catalysts (68) such as sulfuric acid, perchloric acid, trifluoroacetic acid, phosphoms pentoxide, 2inc chloride, ferric chloride, sodium acetate, and tertiary amines, eg, 4-dimethylaminopyridine. 

Acylation of pyridazinones and related compounds in the presence of weakly basic catalysts such as pyridine or sodium acetate produces IV-acylated products, while O-acylated products are obtained under strongly basic conditions. However, the reaction between 6-chloropyridazin-3(2//)-one with chlorocarbonates and that of maleic hydrazide with unsaturated acid chlorides or chloromethylsulfonyl chloride gives preferentially N-substituted products. 

In recent years vinyl acetate has been prepared in large quantities by oxidation of ethylene. If ethylene is passed into a solution of palladium chloride in acetic acid containing sodium acetate, then vinyl acetate, ethylene diacetate and acetaldehyde are produced, the vinyl acetate being obtained in good yields by the reaction shown in Figure 14.3... 

A one-stage process for producing vinyl acetate directly from ethylene has also been disclosed. In this process ethylene is passed through a substantially anhydrous suspension or solution of acetic acid containing cupric chloride and copper or sodium acetate together with a palladium catalyst to yield vinyl acetate. 

---