Silicon toxicology

Busch, H., Silicone toxicology, Semin. Arthr. Rheum., 24, 11, 1994. 

Properties Lt. straw clear to hazy liq. sol. in IPA, ethanol, 1,1,1-chloroethane, xylene, toluene disp. in min. spirits, hydrocarbon and chlorinated hydrocarbon soivs. insol. in water m.w. 11,500 sp.gr. 1.03 dens. 8.5 Ib/ l vise. 6500 cSt f.p. -50 F b.p. > 200 C flash pt. (PMCC) > 93 C nonionic 100% act., 31% silicone Toxicology Essentially nontoxic may cause temper eye discomfort, mild redness, dryness on direct contact no injury likely from relatively short exposure by inh. swallowing Ig. amts, may cause digestive discomfort TSCA listed... 

Properties Wh. milky liq. mild odor water-disp. sp.gr. 0.98-1.01 dens. 8.17-8.42 Ib/gal b.p. 212 F flash pt. none to 212 F pH 7.0-7.3 (5% aq. disp.) 3% silicone Toxicology May cause si. skin and eye irritation Hazardous Ingredients None HMIS Health 0, Flammability 0, Reactivity 0 Storage Store in well-ventilated area below 120 F keep from freezing Trans-1030 D [Trans-Chemco]... 

Properties Yel. powd. odorless sol. > 10 g/l in water m.p. > 200 C 10% silicone Toxicology May cause nausea, si. skin irritation Hazardous Ingredients Silicone (10%)... 

Stokinger HE The halogens and the non-metals boron and silicon. In Clayton GD, Clayton FE (eds) Patty s Industrial Hygiene and Toxicology, 3rd ed, rev, Vol 2B, Toxicology, pp 2965-2968. New York, Wiley-Interscience, 1981... 

Rowe VK, Spencer HC, Bass SL Toxicological studies on certain commercial silicones and hydrolyzable silane intermediates. J Ind Hyg Toxicol 30 332-353, 1948... 

Toxicology. Silicon appears to be a biologically inert material. 

Little information is available on the toxicology of pure elemental silicon, which is an inert material that appears to lack the property of causing fibrosis in lung tissue. Silicon dust gave an inert response on intraperitoneal injection into guinea pigs and rats. Another study, however, reported minimal pulmonary lesions in rabbits after the intratracheal injection of silicon dust at a high level of 25 mg. ... 

Toxicology. Silicon carbide, in certain forms, may be a cause of pneumoconiosis in exposed workers. 

Bruch J, Rehn B, Song W, et al Toxicological investigations on silicon carbide. 2. In vitro cell tests and long term injection tests. BrJlndMed 50 807-813, 1993... 

Toxicology. Silicon tetrahydride is considered to be a skin, eye, and mucous membrane irritant. 

X-ray fluorescence can be used to analyse all types of samples. Its applications are numerous, whether in research and development or in quality control of production. Initially, X-ray fluorescence was used in industries that treat metals of primary fusion or alloys and, more generally, in the mineral industry (for use one ceramics, cements, steel, glass, etc.). Because of the ease of use of common X-ray fluorescence instruments, its scope of application has expanded into other areas the photographic industry and semi-conductors (for impurity control in silicon chips), the petroleum industry, geology, paper mills, gas analyses (such as nitrogen), toxicology and environmental applications (dust, fumes from combustion, heavy metals, and dangerous materials in waste such as Pb, As, Cr, Cd, etc.). 

Toxicological investigations (white mice, i.p.) of compounds 96a 99a and 96b-99b indicated that there is no significant difference in acute toxicity between the silicon compounds and their corresponding carbon analogues (cf. Table 11). 

With reference to this point of view a large amount of bioactive silicon compounds with a short duration of action was synthesized and investigated in pharmacological and toxicological effects. 

Toxicological tests121 (white mice, i.p.) resulted also in significant differences. The silicon compound was found to be more toxic than its carbon analogue. It is not clear so far, whether this difference is connected with the hydrolysis or not. 

Because of its use in semiconductors, silicon has emerged as a key element in modem technology. Concurrent with this phenomenon has been an awareness of the toxicity of silicon compounds, many of which, fortunately, have relatively low toxicities. This section covers the toxicological aspects of inorganic silicon compounds. 

What is the most commonly produced silicon tetrahalide How is it used Why might its toxicological properties be similar to those of HC1 ... 

Voronkov, M. G., Zelchan, G. I., and Lukevitz, E. Y., Silicon and Life Biochemistry, Toxicology, and Pharmacology of Silicon Compounds. Zinatne Publ., Riga, 1971. 

Silicon (Si) is the most abundant element in our environment it constitutes 26% of the earth s crust. From the toxicological viewpoint, several forms of Si are of interest, including amorphous oxides of Si (e.g., asbestos) and methylated polymers of Si (e.g., silicone). 

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