Serous cystadenoma

FIGURE 4.5 Representative spectrum examples of SELDI analysis of pancreatic juice samples bound to IMAC-3 cupper ProteinChip array. A peak of 16,570 Da (arrow) was present in the four pancreatic juice samples from patients with pancreatic adenocarcinoma (PC4, PCS, PC 18, PC24) but absent in the four patients with other pancreatic diseases (IPMN islet cell tumor (ICT) serous cystadenoma (SC)). (Reprinted from Rosty et al. [26], used with permission from the American Association of Cancer Research.)... 

In the pancreas and ampulla, the glandular/ductal system is characterized and distinguished by mucin production. With the exception of centroacinar cells/intercalated ducts in the pancreas and the serous cystadenomas that presumably recapitulate this earliest component of the ductal system, virtually all glandular elements... 

Serous cystadenoma (SCA) is the only nonmucinous example of ductal neoplasia in the pancreas and, unlike other ductal tumors, has virtually no tendency for malignant transformation. It is also known to have a well-established association with von Hippel-Lindau (vHL) syndrome. iez... 

FIGURE 15.15 GLUT-1 expression in serous cystadenoma is detected predominantly in the cell membranes, but also in the... 

FIGURE 15.16 The remarkable Intensity of capillary network Immediately adjacent to the epithelium, highlighted by CD31, In serous cystadenoma. 

Clear cell variant of pancreatic endocrine neoplasm versus serous cystadenoma Diffuse immuno-reactivityforchromogranin and synaptophysin is highly in favor of an endocrine origin. 

Alpert LC, Truong LD, Bossart MI, Spjut HJ. Microcystic adenoma (serous cystadenoma) of the pancreas. A smdy of 14 cases with immunohistochemical and electron-microscopic correlation. Am J Surg Pathol. 1988 12 251-263. 

Shorten SD, Hart WR, Petras RE. Microcystic adenomas (serous cystadenomas) of pancreas. A clinicopathologic investigation of eight cases with immunohistochemical and ultrastructural smd-ies. Am J Surg Pathol. 1986 10 365-372. 

Perez-Ordonez B, Naseem A, Lieberman PH, Klimstra DS. Solid serous adenoma of the pancreas. The solid variant of serous cystadenoma Am J Surg Pathol. 1996 20 1401-1405. 

Ishikawa T, Nakao A, Nomoto S, et al. Immunohistochemical and molecular biological studies of serous cystadenoma of the pancreas. Pancreas. 1998 16 40-44. 

Thirabanjasak D, Basturk O, Altinel D, et ak Is serous cystadenoma of pancreas a model of clear cell associated angiogenesis and tumorigenesis Pancreatology. 2008 9 182-188. 

Serous cystadenomas account for up to 40% of all benign ovarian neoplasms. They show a peak incidence in the fourth and fifth decades and are in up to 20% bilateral. Mucinous cystadenomas account for 20%-25% of all benign ovarian neoplasms, and are bilateral in only 2%-3% of cases. Both are cystic lesions filled with water-like or... 

Mucinous cystadenomas tend to be multilocular and larger at the time of presentation than serous cystadenomas. They present with a mean size of 10 cm,but maybe as large as 30 cm [1]. 

The serous cystadenoma (formally known as microcys-tic cystadenoma) predominantly affects women in the sixth to seventh decade. Quite often, it is incidentally detected, when CT studies performed for clinical symptoms unrelated to the pancreas. Serous cystadenoma is a benign tumor, with no more than 10 cases of serous cystadenocarcinoma reported worldwide. Thus, in clinical practice there is no risk of maUgnant degeneration, which may direct clinical management of these tumors more toward foUow-up. 

The typical CT features of more common microcys-tic serous cystadenoma are multiple (usually more than six) small cysts that range from a few miUimeters up to 2 cm in size, which tend to give the lesion an inhomogeneous, hypodense pseudosolid appearance at contrast-enhanced CT (Sahani et al. 2005). Actually, there are no sohd nodules in serous cystadenoma present, but the multitude of tiny septations and cyst walls may give... 

Fig. 30.7a-c. Serous cystadenoma a Axial CT demonstrates a multicystic mass in the pancreatic head and neck, which (b) is better seen on the coronal MPR (arrows), c However, the internal structure of the lesion with multiple, small cysts is better appreciated on the axial T2-weighted MR image... 

Mucinous cystadenoma usually occur in women. In contrast to (the always benign) serous cystadenoma, mucinous tumors represent a histologic spectrum, ranging from adenoma, borderline tumor to non-invasive and invasive carcinoma. With advancing age, the histologic grade of the tumor tends to worsen. The CT appearance is always macrocystic (therefore the synonym... 

Ebert AD, Rosenow G, David M, Mechsner S, Magalov IS, Papadopoulos T. Co-occurrence of atypical endometriosis, subserous uterine leiomyomata, sactosal-pinx, serous cystadenoma and bilateral hemorrhagic corpora lutea in a perimeno-pausal adipose patient taking tamoxifen (20 mg/day) for invasive lobular breast cancer. G5mecol Obstet Invest 2008 66 209-13. 

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