Serotonin receptor genes

Puentes, J. A., Lauzurica, N., Hurtado, A., et al. (2004) Analysis of the -1438 G/A polymorphism of the 5-HT2A serotonin receptor gene in buUmia nervosa patients with or without a history of anorexia nervosa. Psychiatr. Genet. 14,107-109. 

Warren JT Jr, Peacock ML, Fink JK. An Rsal polymorphism in the human serotonin receptor gene (HTR1 A) detection by DGGE and RFLP analysis. Hum Mol Genet 1992 1 778. 

Kawahara H, Isoai A, Shizuri Y. Molecular cloning of a putative serotonin receptor gene from barnacle, Balanus amphitrite. Gene 1997 184 245-250. 

Foguet M, Nguyen H, Le H, Lubbert H. Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes. Neuroreport 1992 3 345-348. 

Holmes C, et al. Depression in Alzheimer s disease the effect of serotonin receptor gene variation. Am J Med Genet 2003 119B(l) 40-43. 

Niesler B, Flohr T, Nothen MM, et al. Association between the 5 UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder. Pharmacogenetics 2001 11(6) 471-475. 

Rebeck, G.W., Maynard, K.I., Hyman, B.T. and Moskowitz, M.A. (1994) Selective 5-HTiDa serotonin receptor gene expression in trigeminal ganglia implications for antimigraine drug development. Proc. Natl. Acad. Set. USA, 91, 3666-3669. 

The serotonin 6 (5-HT6) receptor is one of the most recently studied serotonin receptors, and an important candidate gene for the study of MDD because it is abundant in the limbic system and some antidepressants have a high affinity for it (Monsma, Shen, Ward etal, 1993). 

Erdmann, J., Shimron-Abarbanell, D., Rietschel, M. etal. (1996). Systematic screening for mutations in the human serotonin-2A (5-HT2a) receptor gene identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum. Genet., 97, 614-19. 

Masellis, M., Basile, V. S., Meltzer, H. Y. etal. (2001). Lack of association between theT->C 267 serotonin 5-HT 6 receptor gene (HTR6) polymorphism andprediction of response to clozapine in schizophrenia. Schizophr. Res., 15, 49-58. 

Reynolds, G. P., Zhang, Z. Zhang, X. (2003). Polymorphism of the promoter region of the serotonin 5HT(2C) receptor gene and clozapine induced weight gain. Am. J. Psychiatry, 160, 677-9. 

Serretti, A., Lorenzi, C., Lilli, R. Smeraldi, E. (2000). Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders. /. Psychiatr. Res., 34, 89-98. 

Vogt, I. R., Shimron-Abarbanell, D., Neidt, H. etal. (2000). Investigation ofthehuman serotonin 6 [5HT6] receptor gene in bipolar affective disorder and schizophrenia. Am. J. Med. Genet., 96,217-21. 

Inayama Y, Yoneda H, Sakai T, Ishida T, Nonomura Y, Kono Y et al. Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am J Med Genet 1996 67[1] 103 105. 

Masellis M, Basile V, Meltzer HY, Lieberman JA, Sevy S, Macciardi FM et al. Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients. Neuropsychopharmacology 1998 19(2) 123—132. 

Segman RH, Heresco-Levy U, Finkel B, Goltser T, Shalem R, Schlafman M et al. Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia. Mol Psychiatry 2001 6(2) 225-229. 

Finally, RNA editing can be involved, as in the case of the amphibian bombesin-like peptides, where nucleotides in the mRNA are changed and the final protein is not a direct reflection of the sequence encoded in the gene. RNA editing is also seen in the glutamate (Ch. 15) and serotonin receptors (Ch. 13 and Ch. 15) and probably will be found elsewhere as detection methods become more sophisticated. 

Many studies have shown associations of SNPs in such genes as the serotonin 5-HT and 5-HT receptors, genes and the histamine receptor gene, not to the phenotype of disease severity, but to phenotypes such as drug response or nonresponse (97). For example, the S-HT receptor gene variants and the variant that encodes the Cys22Ser receptor have been associated with altered responses to clozapine (97). 

Levitan, R. D., Masellis, M., Basile, V. S., et al. (2002) Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder. J. Ajfect. Disord. 71, 229-233. 

Vaquero, L. C., Baca-Garda, E., az-Hemandez, M., et al. (2006) Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry. 30, 1136-1138. 

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