Serotonin 6 receptor gene polymorphism

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Warren JT Jr, Peacock ML, Fink JK. An Rsal polymorphism in the human serotonin receptor gene (HTR1 A) detection by DGGE and RFLP analysis. Hum Mol Genet 1992 1 778. 

Assal F, et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. Arch Neurol 2004 61(8) 1249-1253. 

Ranade SS, et al. Linkage and association between serotonin 2A receptor gene polymorphisms and bipolar I disorder. Am J Med Genet 2003 121B(l) 28-34. 

Ohtsuki T, et al. Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees. Mol Psychiatry 2002 7(9) 954-961. 

Simpson DA, Headley PM, Lumb BM (2008) Selective inhibition from the anterior hypothalamus of C- versus A-fibre mediated spinal nociception. Pain 136 305-312 Singh VP, Jain NK, Kulkarni SK (2001) On the antinociceptive effect of fluoxetine, a selective serotonin reuptake inhibitor. Brain Res 915 218-226 Sipe JC, Arbour N, Gerber A, Beutler E (2005) Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism possible risk for autoimmune disorders. J Leukoc Biol 78 231-238... 

Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR. Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin lA receptor gene polymorphism. J. Neurosci. 2006 26 1864-1871. 

Ono H, Shirakawa O, Nishiguchi N et al (2001) Serotonin 2A receptor gene polymorphism is not associated with completed suicide. J Psychiatr Res 35 173-176... 

Masellis, M., Basile, V. S., Meltzer, H. Y. etal. (2001). Lack of association between theT->C 267 serotonin 5-HT 6 receptor gene (HTR6) polymorphism andprediction of response to clozapine in schizophrenia. Schizophr. Res., 15, 49-58. 

Reynolds, G. P., Zhang, Z. Zhang, X. (2003). Polymorphism of the promoter region of the serotonin 5HT(2C) receptor gene and clozapine induced weight gain. Am. J. Psychiatry, 160, 677-9. 

Masellis M, Basils VS, Meltzer HY, Lieberman JA, Sevy S, Goldman DA et al. Lack of association between the T to C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. Schizophr Res 2001 47(1) 49—58. 

Levitan, R. D., Masellis, M., Basile, V. S., et al. (2002) Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder. J. Ajfect. Disord. 71, 229-233. 

Vaquero, L. C., Baca-Garda, E., az-Hemandez, M., et al. (2006) Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry. 30, 1136-1138. 

Chen, R. Y., Sham, P., Chen, E. Y., et al. (2001) No association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patients. Psychiatry Res. 105, 175-185. 

Czerskl, P. M.,Leszczynska-Rodziewicz, A., Dmitrzak-Weglarz,M.,et al. (2003) Association analysis of serotonin 2A receptor gene T102C polymorphism and schizophrenia. World J. Biol. Psychiatry. 4, 69-73. 

Yuan, X., Yamada, K., Ishiyama-Shigemoto, S., Koyama, W., and Nonaka, K. (2000) Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes. Diabetologia. 43,373-376. 

Elhngrod, V. L., Miller, D., Ringold, J. C., and Perry, P. J. (2004) Distribution of the serotonin 2C (5HT2C) receptor gene -759C/T polymorphism in patients with schizophrenia and normal controls. Psychiatr. Genet. 14,93-95. 

Ickowicz, A., Feng, Y., Wigg, K., et al. (2007) The serotonin receptor HTRIB Gene polymorphisms in attention deficit hyperactivity disorder. Am. J. Med. 144B, 121-125. 

Maestrini, E., Lai, C., Marlow, A., Matthews, N., Wallace, S., Bailey, A., Cook, E., Weeks, D., Monaco, A., and International Molecular Genetics of Autism Consortium. (1999) Serotonin transporter (S-HTT) and gamma-aminobuyric acid receptor subunit beta-3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. Am J Med Genet (Neuropsychiatr Genet), 88 492-496. 

Hinney, A., Herrmann, H., Lohr, T, Rosenkranz, K., Ziegler, A., Lehmkuhl, G., Poustka, R., Schmidt, M.H., Mayer, H., Siegfried, W, Remschmidt, H., and Hebebrand, J. (1999a). No evidence for involvement of alleles of polymorphisms in the serotonin IDbeta and 7 receptor genes in obesity, underweight or anorexia nervosa. Int J Obes Rel Metab Disord 23 760-763. 

Several studies have discussed the relationship between serum cholesterol and suicide, violence, anxiety disorders, depressive disorders, and schizophrenia [1-3]. Some of these papers suggested that low or lowering cholesterol levels could cause or worsen depressive symptoms and increase the risks of suicide and violence death. There are many reports that discussed the relationships between the lipid profiles, depression, and suicide from the viewpoints of decreased serotonergic transmission on suicide behavior [4, 5], lower serum cholesterol and serotonin levels [6, 7], serum cholesterol levels and polymorphism in the promoter region of the serotonin transporter gene for depression and suicide [8-10], low serum cholesterol and suicide risk [11, 12], and serotonergic receptor function [13, 14]. These studies supported the hypothesis that reduced cholesterol levels resulted in reduced central serotonin transmission. 

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