Serine palmitoyltransferases

Perry, D.K., Carton, J., Shah, A.K., Meredith, F., Uhlinger, D.J., and Hannun, Y.A., 2000, Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J. Biol. Chem. 275 9078-9084. 

SERINE PALMITOYLTRANSFERASE SUCCINYL-CoA SYNTHETASE TRANSCARBOXYLASE VINYLACETYL-CoA ISOMERASE COENZYME Q (Ubiquinone)... 

SERINE PALMITOYLTRANSFERASE 3-DEHYDROSPHINGANINE REDUCTASE DEINHIBITION Delayed fluorescence,... 

SERINE DEHYDRATASE SERINE DEHYDROGENASE SERINE HYDROXYMETHYLTRANSFERASE SERINE PALMITOYLTRANSFERASE Serine deaminase... 

SERINE DEHYDRATASE SERINE DEHYDRATASE SERINE DEHYDROGENASE Serine esterase inhibitor, irreversible, PHENYLMETHYLSULFONYL FLUORIDE SERINE HYDROXYMETHYLTRANSFERASE SERINE PALMITOYLTRANSFERASE Serine protease inhibitor, irreversible, PHENYLMETHYLSULFONYL FLUORIDE Serine proteinase inhibitor,... 

Serine hydro xymethyltransferase Threonine aldolase 8-Aminolevulinate synthase Serine palmitoyltransferase 2-Amino-3-oxobutyrate-CoA ligase... 

Fig. 6.9 Serine palmitoyltransferase (SPT) immunoreactivity in field CA1 of the hippocampus. A section from a normal rat, showing light labeling in pyramidal neurons (arrowheads). B section from a rat that had been injected with kainate 2 weeks earlier, showing loss of labeling in neurons, but increased labeling in astrocytes (arrows). Scale = 50 ftm. Reproduced with kind permission from He et al., 2005, Journal of Neuroscience Research 85 423 132. Wiley-Liss...

Hanada K. (2003). Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim. Biophys. Acta 1632 16-30. 

Riley, R. T., Voss, K. A., Norred, W. P., Bacon, C. W., Meredith, F. I., and Sharma, R. P. (1999). Serine palmitoyltransferase inhibition reverses antiproliferative effects of ceramide synthase inhibition in cultured renal cells and suppresses free sphingoid base accumulation in kidney of BALBc mice. Environ. Toxicol. Pharmacol. 7,109-118. 

Kobayashi S, Furuta T, Hayashi T, Nishijima M, Hanada K (1998) Catalytic asymmetric syntheses of antifungal sphingofungins and their biological activity as potent inhibitors of serine palmitoyltransferase (SPT). J Am Chem Soc 120 908... 

The vitamin also activates serine palmitoyltransferase, the first enzyme of phosphosphingolipid synthesis, and in bacteria it can, together with inorganic phosphate, replace part of the ATP requirement of galactocerebroside sulfo-transferase (Tsaioun, 1999). In animals, lipid sulfatides are decreased in vitamin K deficiency and increased with higher intakes (Sundaram et al., 1996). 

Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Nai-smith JH, Campopiano DJ. The structure of serine palmitoyltransferase gateway to sphingolipid biosynthesis. J. Mol. Biol. 2007 370 870-886. 

Hanada K, Nishijima M, Fujita T, Kobayashi S. Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant. Biochem. Pharmacol. 2000 59 1211-1216. 

Ikushiro H, Hayashi H, Kagamiyama H. Reactions of serine palmitoyltransferase with serine and molecular mechanisms of the actions of serine derivatives as inhibitors. Biochemistry 2004 43 1082-1092. 

HPR-mediated leukemia cell c)4otoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bcl-2. Free Radical Res. 2007 41 591-601. Wang H, Maurer BJ, Reynolds CP, Cabot MC. N-(4-Hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase. Cancer Res. 2001 61 5102-5105. Bandhuvula P, Tam YY, Oskouian B, Saba JD. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J. Biol. Chem. 2005 280 33697-33700. 

Kobayashi, S., Furuta, T., Hayashi, T., Nishijima, M., Hanada, K. Catalytic Asymmetric Syntheses of Antifungal Sphingofungins and Their Biological Activity as Potent Inhibitors of Serine Palmitoyltransferase (SPT). J. Am. Chem. Soc. 1998, 120, 908-919. 

Geekiyanage H, Upadhye A, Chan C (2013) Inhibition of serine palmitoyltransferase reduces A(1 and tau hyperphosphorylation in a murine model A safe therapeutic strategy for Alzheimer s disease. Neurobiol Aging 34 2037-2051... 

Unger, Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression, J. 

Dawkins JL, Hulme DJ, Brahmbhatt SB, Auer-Grumbach M, Nicholson GA. 2001. Mutations in SPTLCl, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type 1. Nat Genet 27 309-312. 

Miyake, Y., Kozutsumi, Y., Nakamura, S., Fujita, T., Kawasaki, T. (1995). Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-l/myriocin. Biochem. Biophys. Res. Commun., 211, 396-403. 

Batheja AD, Uhlinger DJ, Carton JM, Ho G, D Andrea MR. Characterization of serine palmitoyltransferase in normal human tissues. J Histochem Cytochem 51(2003) 687-696. 

Hornemann T, Richard S, Rutti MF, Wei Y, von Eckardstein A. Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase. J Biol Chem 281(2006) 37275-37281. 

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