Sphingolipid metabolism

Merrill AH, Sweeley CC Sphingolipids metabolism and cell signaling. In Biochemistry of Lipids, Lipoproteins and Membranes. Vance DE, Vance JE (editors). Elsevier, 1996. 

Volume 311. Sphingolipid Metabolism and Cell Signaling (Part A)... 

Figure 1. Scheme of sphingolipid metabolism and the central role of ceramide and ceramidases. 

B. Kaufman, 8. Basu, and S. Roseman, in 8. M. Aronson and B. N. Volk (Eds.), Inborn Disorders of Sphingolipid Metabolism, Proc.. Int. Symp. Cerebral Sphin-golipidoses, 3rd, Pergamon Press, Oxford and New York, 1966, pp. 193-213. 

Scriver, C. R., A. I. Beaudet, W. S. Sly, and D. Valle (eds.), The Metabolic Basis of Inherited Disease, 6th ed., vol. 2, New York McGraw Hill, 1989. This book contains in-depth chapters on sphingolipid metabolism and many of the sphingolipidoses. 

Hanada K. (2003). Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim. Biophys. Acta 1632 16-30. 

During the past decade, several reports have demonstrated the decline of sphingolipid metabolism in atopic dermatitis24,25 and the cause of dry skin has been shown to be the abnormality of sphingolipid metabolism.26 However, in experimentally induced dry skin, the total amount of SC ceramide did not change13,26 but the amino acid content decreased.13 Recently, Tanaka etal. reported27 that amino acid content was reduced in the SC in atopic respiratory disease. They suggested that the free amino acid content is the crucial factor of the dry, scaly features of not only experimentally induced... 

The chemical structure of fumonisin (Fig. 5.IB) is remarkably similar to that of the sphingoid bases sphinganine (Sa) and sphingosine (So), and fumonisin has been shown to inhibit the enzyme ceramide synthase in de novo sphingolipid metabolism (Wang et al., 1991). Ceramide synthase... 

Sphingolipid metabolism is also affected by cytokines and other signaling molecules. Tumor necrosis factor a (TNFa) is a cytokine that... 

Marasas, W. F., Riley, R. T., Hendricks, K. A., Stevens, V. L., Sadler, T. W., Gelineau-van Waes, J., Missmer, S. A., Cabrera, J., Torres, O., Gelderblom, W. C., Allegood, J., Martinez, C., et al. (2004). Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo A potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. J. Nutr. 134(4), 711-716. 

Mizugishi, K., Li, C., Olivera, A., Bielawski, J., Bielawski, A., Deng, C. X., and Proia, R. L. (2007). Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J. Clin. Invest. 117(10), 2993-3006. 

Ramasamy, S., Wang, E., Pfennig, B., and Merrill, A. H., Jr. (1995). Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. Toxicol. Appl. Pharmacol. 133(2), 343-348. 

Kanfer, J. N. (1983) Sphingolipid metabolism, in Handbook of Lipid Research, Vol. 3, J.N. Kanfer and S.-i. Hakomori, editors, Plenum Press, New York, pp. 167-247. 

Smith, W.L., Merrill, A.H. 2002. Sphingolipid metabolism and signaling minireview series J. Biol. Chem. 211, 25841-25842. 

Pfeuffer, M., Schrezenmeir, J. 2001. Sphingolipids metabolism and implications for health, Bulletin International Dairy Federation, Brussels, 363, pp. 47-51. 

Dunn, T.M., Lynch, D.V, Michaelson, L.V, and Napier, J.A., 2004, A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana. Ann. Bot. (Lond.) 93 483 197. 

Sims, K.J., Spassieva, S.D., Voit, E.O., and Obeid, L.M., 2004, Yeast sphingolipid metabolism Clues and connections. Biochem. Cell Biol. 82 45-61. 

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