Serine formula

Strategy Write the condensation reaction that takes place between glycine and serine. To do this, start with the structural formulas of the two amino acids, glycine at the left, serine at the right. In each case, put the NH2 group at the left, the COOH group at the right. Condense out a water molecule what is left is the structural formula of Gly-Ser. 

Give the structural formula of two different dipeptides formed between arginine and serine. 

C18-0142. The amine group of an amino acid readily accepts a proton, and the protonated form of an amino acid can be viewed as a diprotic acid. The p Zg values for serine (H2 NCHRCO2 H, i = CH2 OH) are p ra(H3 N"") =9.1 and p (002 H) - 2.2. (a) What is the chemical formula of the species that forms when serine dissolves in pure water (b) If this species is titrated with strong acid, what reaction occurs (c) 10.00 mL of 1.00 M HCl is added to 200. mL of 0.0500 M serine solution. This mixture is then titrated with 0.500 M NaOH. Draw the titration curve, indicating the pH at various stages of this titration. 

Kikuchi, O., T. Matsuoka, H. Sawahata, and O. Takahashi. 1994. Ab Initio Molecular Orbital Calculations Including Solvent Effects by Generalized Born Formula. Conformation of Zwitterionic Forms of Glycine, Alanine and Serine in Water. J. Mol. Struct. (Theochem) 305, 79-87. 

To rationalize the stereospecificity of PLE toward a large variety of monocarboxylic and dicarboxylic esters, Tamm and co-workers have proposed the general formula displayed in Fig. 7.5 [5 5] [67]. Here, no representation of the active site is implied, but the model does rationalize numerous data and allows some qualitative predictions. A qualitative topographical model of the active site of PLE has been proposed by Jones and co-workers [68] [69], As shown in Fig. 7.6, substrate binding is defined by a carboxylate group that interacts with the catalytic serine residue, and by one or two hydrophobic groups that bind to sites 1 and/or 2. 

Fig. 7.5. General formula summarizing the structural and stereochemical requirements, which an ester should meet to fit into the active site of pig liver esterase. A nucleophilic attack by the serine OH group seemingly occurs from this side B no or only small substituents allowed here C groups of small to medium size allowed in this area D space allowed in these areas for carbon chains, with polar substituents (e.g., another ester group) preferred in the upper part ...

Serine (Ser or S) ((S)-2-amino-3-hydroxypropanoic acid) is a polar, neutral, uncharged amino acid with the formula H00CCH(NH2)CH20H. It has an aliphatic hydroxyl side chain and can be seen as a hydroxylated version of Ala. Ser participates in the biosynthesis of purines and pyrimidines and is also the precursor to several amino acids including Gly, Cys, and Trp (in bacteria). In addition, it is the precursor to numerous other metabolites, including sphingolipids and is present in enzymes such as a-chymotrypsin. Ser, Asn, and aspartate disrupt a helices. 

Using partial structural formulas, describe the reactions by which serine and methionine react to form N-formy I methionine needed for protein synthesis. 

Chemical Name DL-Serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide Common Name -Structural Formula ... 

Cyclotene is the precursor of dihydrocyclopentapyrazines after having reacted with ammonia respectively amino acids to form cyclotene imine. Figure 2 demonstrates not only the isomerization and transformation of this compound but also the formula of bis-dihydro-cyclopentapyrazines as special reaction products. They are formed by condensation of cyclotene-imine and represent a mixture of 4 di-astereomeric compounds. These compounds produce identical mass spectra (Shibamoto et a 1,16). We have carried out corresponding experiments by heating Furaneol with phenylalanine or serine in an autoclave at 180 0 C. As Figure 3 demonstrates some monocyclic pyrazines are formed by reaction of the degradation products from Furaneol. 

A particularly striking feature of the simplified formula of the tobacco mosaic virus (Fig. 14) is the stereotype repetition of several simple structures (combinations UI, LS, AF) which in fact represent the cornerstones of the entire molecule. A phenomenon deserving special interest (apart from a number of symmetrical sequences occurring along the whole chain) is the symmetrical arrangement of the dipeptides of the hydroxyamino acid residues at both terminals of the polypeptide chain. This relative concentration of the serine residues at the ends of the tobacco mosaic virus protein chain has been pointed out by Anderer et al. (1960) as a possible example of nonrandomness. 

The structural formulas of phosphatidyl choline and the other principal phosphoglycerides—namely, phosphatidyl ethanolamine, phosphatidyl serine, phosphatidyl inositol, and diphosphatidyl glycerol—are given in Figure 12.5. 

Structural formulae of L-alanyl-L-serine (ala-ser) and L-alanyl-L-histidine (ala-his) in their zwitterionic representation, and proposed structures of the predominant vanadate complexes. For the ala-ser complexes, see also the speciation diagram in Figure 2.16. 

Give the general formula for an amino acid. Some amino acids are labeled hydrophilic and some are labeled hydrophobic. What do these terms refer to Aqueous solutions of amino acids are buffered solutions. Explain. Most of the amino acids in Fig. 22.18 are optically active. Explain. What is a peptide bond Show how glycine, serine, and alanine react to form a tripeptide. What is a protein, and what are the monomers in proteins Distinguish between the primary, secondary, and tertiary structures of a protein. Give examples of the types of forces that maintain each type of structure. Describe how denaturation affects the function of a protein. 

The species H2Ar, HAl", andAl correspond to the forms H2B,HB andB of ordinary dibasic acids of the formula H2B. Certainly, there is also an equilibrium of intramolecular proton transfer, i.e., a tautomeric equilibrium HAl HAl. However, its equilibrium constant is so large that the concentration of HAl is very small. In ethanol-water mixtures as solvent, the respective equilibrium constants of glycine, L-alanine, L-valine, L-leucine, L-phenylalanine, L-isoleucine, L-methionine, and L-serine are aU between 10 and 10 [8]. 

Write a complete stractural formula and an abbreviated formula for the tripeptide formed from tyrosine, serine, and phenylalanine in which the C-terminal residue is serine and the N-terminal residue is phenylalanine. 

Definition Ester of ethyl alcohol and serine Empirical C5H11NO3 Formula HOCH2CHNH2COOCH2CH3 Uses Antistat in cosmetics Ethyl silicate... 

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