Phosphatidyl-ethanolamine

Lecithin. Lecithin [8002-43-5] (qv) is a mixture of fat-like compounds that includes phosphatidyl choline, phosphatidyl ethanolamines, inositol phosphatides, and other compounds (37). Commercial lecithin was originally obtained from egg yolks, but is now extracted from soybean oil. Lecithin is used in many products, including margarine, chocolate, ice cream, cake batter, and bread. 

Phosphatidic acid Phosphatidylcholine Phosphatidyl- ethanolamine Phosphatidylserine... 

Hauser, H., Pascher, I., Pearson, R.H. Sundell, S. (1981). Preferred conformation and molecular packing of phosphatidyl ethanolamine and phosphatidylcholine. Biochimica Biophysica Acta, 650, 21-51. 

WENG x c and Gordon m h (1993) Antioxidant synergy between phosphatidyl ethanolamine and oc-tocopherylquinone . Food Chem, 48 (2) 165-8. 

Abbreviations EPR, electron paramagnetic resonance FITC, fluorescein-5 -isothiocyanate lAEDANS, iV-iodoacetyl-N -(5-sulfo-l-naphthyl)ethylenediamine NCD, fluorescent yV-cyclohexyl-N -(4-dimethyl-amino-a-naphthyl)carbodiimide RITC, rhodamine-5 -isothiocyanate DPPE, dipalmitoylphosphatidyl-ethanolamine PE, egg phosphatidyl-ethanolamine ANS, 8-anilino-l-naphthalene sulfonate DPH, diphenylhexatriene e-ADP, l,iV -ethanoadenosine-5 -diphosphate TNP-ADP, 2 [3 ]-0-(2,4,6-trinitrophe-nyl)adenosine-5 -diphosphate. 

Soya lecithin is a natural product which contains about 34% glycerides (soya oil), 5% sugars, and 61% phosphatides. The phosphatides in turn are comprised of phosphatidyl choline, i.e., chemical lecithin (20%), phosphatidyl ethanolamine (20%), and phosphatidyl inositol (21%). 

Analogues of phosphatidyl ethanolamine, phosphatidyl choline, and phosphatidic acid with pantoic acid skeleton were prepared by phosphorylation with the respective phosphoric mono-, bis-, and tristriazolide [17]... 

FIGURE 2-10 Tracking a gold particle attached to a single molecule of phosphatidyl ethanolamine. What appears to be simple Brownian diffusion at a time resolution of 33 ms per video frame (A) is revealed to actually consist of fast hop diffusion by recording 300 times faster (B) at 110 ps per video frame. In (A) each color represents 60 frames = 2 seconds. In (B) each color indicates an apparent period of confinement within a compartment and black indicates intercompartmental hops. The residency time for each compartment is indicated. The hypothetical explanations are illustrated in part (C) and discussed in the text. Adapted from [29]. 

MDP-PE, muramyl tripeptide phosphatidyl, Ethanolamine Lipoidal tripeptide Macrophage activating agent Osteosarcomas... 

Figure 7. Lipophilicity profile of propranolol in liposomes composed of zwitterionic and charged lipids (phosphatidyl ethanolamine (PE), oleic acid (OA), phosphatidyl inositol (PI)). Conditions of measurements are described in [113]. The dotted line indicates the partitioning profile of propranolol in the egg PC liposome system. The bars show the pH-dependent charge profile of propranolol (hatched bars positively charged propranolol) and the lipids in the membrane (black bars negatively charged lipids). Reprinted from [113] Kramer, S. (2001). Liposome/water partitioning , In Pharmacokinetic Optimization in Drug Research, eds. Testa, B. et al. Reproduced by permission of Verlag Helvetica Chimica Acta, Zurich...

Phosphatidyl ethanolamines —ch2ch2nh3 Large amounts in animals, plants and microorganisms Old trivial name is cephalin. Methyl and dimethyl ethanolamine derivatives also occur... 

Acid glycerophosphatides Phosphatidyl ethanolamine Lecithin Sphingomyelin Lysolecithin... 

Phosphatidic acid Phosphatidyl ethanolamine Phosphatidyl serine Phosphatidyl choline Phosphatidyl inositol Sphingomyelin. 

Ninhydrin 2 g 1 1 in acetone Containing free amino groups Purple spots appear with phosphatidyl ethanolamine and phosphatidyl serine, for instance, after heating at 100°C... 

The 31P n.m.r. of phospholipids has been the subject of a number of papers.62-89 These have been primarily aimed at investigating the conformation and motion of phospholipids in bilayers, but information has also been obtained on gel-to-liquid crystal transformations of phospholipids.65-67 A P31 1H nuclear Overhauser effect indicates that there is little tendency for mixed phosphatidylcholine/phosphatidyl-ethanolamine vesicles to segregate in separate domains.68 69 A phosphonium analogue (23) of choline chloride has been prepared and converted chemically into... 

As shown in Table 1, the acyl moiety of cardiolipin is comprised almost entirely of unsaturated fatty acids. Other membrane phospholipids such as phosphatidyl choline and phosphatidyl ethanolamine contain 1(M0 mol of saturatedfatty acids such as palmitic acid (Ci6 0) and stearic acid (Ci8 0) per 100 mol of total fatty acids. In particular,linoleic acid (Cl8 2) is the most abundant polyunsaturated fatty acid consisting of 80 mol%, linolenic acid (Cl8 3) 8 mol%, and oleic acid (Ci8 i) 6 mol%. Therefore, by using a commercially available cardiolipin purified from bovine heart mitochondria, we characterized auto-oxidation products by reverse phase HPTLC and reverse phase HPLC. 

Sretcher, M.S., 1972b, Phosphatidyl-ethanolamine differential labelling in intact ceUs and cell ghosts of human erythrocytes by a membrane-impermeable reagent J. Mol. Biol., 71 523-528. 

Figure 7 Maximum lipofection efficiencies [RLU (lu/pg protein)] of the most effective lipoplexes of R-configurated KL-1-14 in a mixture with Choi in different Choi/ KL-1-14 ratios from 0.3 to 1.2 (counterion chloride) and the pCMVluc-plasmid (charge ratio 7 or 9). Each bar represents the mean ( S.D.) of three wells of a 96-well microtiter plate. Abbreviations. Choi, cholesterol DOPE, 1,2-dioleoyl-sn-glycero-3-phosphatidyl-ethanolamine RLU, relative light units.

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