Separations molecularly imprinted polymer

Molecularly imprinted polymers have recently attracted much attention because they are denoted as artificial antibodies which are made from simple chemical components via polymerization and can be used for the preparation ofbiomimetic sensors, affinity separation matrices, catalysts, etc. (Figure 1). 

One direct approach to the separation of chiral compounds is called molecular imprint polymers (MIPs) that involves the formation of a three-dimensional cavity with the shape and electronic features that are complementary to the imprinted or target molecule. 

Haupt, K., Molecularly imprinted polymers Artificial receptors for affinity separations, in Handbook of Affinity Chromatography, 2nd edn., Hage, D.S., Ed., CRC Press, Boca Raton, FL, 2005, Chap. 30. 

Takeuchi T, Haginaka J. Separation and sensing based on molecular recognition using molecularly imprinted polymers. J Chromatogr B 1999 728 1-20. 

Wang HJ, Zhou WH, Yin XF, Zhuang ZX, Yang HH, Wang XR. Template synthesized molecularly imprinted polymer nanotube membranes for chemical separations. J Am Chem Soc 2006 128 15954-15955. 

Molecularly imprinted polymers (MIPs) have been used in many different applications, such as affinity separation matrices [6, 7], antibody mimics in immunoassays [8-11], recognition elements in biosensors [12-16], selective... 

Pichon V, Haupt K (2006) Affinity separations on molecularly imprinted polymers with special emphasis on solid-phase extraction. J Liq Chromatogr Related Technol 29(7—8) 989—1023... 

Molecularly imprinted polymers with a variety of shapes have also been prepared by polymerizing monoliths in molds. This in situ preparation of MIPs was utilized for filling of capillaries [20], columns [21], and membranes [22, 23]. Each specific particle geometry however needs optimization of the respective polymerization conditions while maintaining the correct conditions for successful imprinting. It would be advantageous to separate these two processes, e.g., to prepare a molecularly imprinted material in one step, which then can be processed in a mold process in a separate step to result the desired shape. 

Polymer libraries are covered according to their numerous applications, each described through a specific example. The reported examples include libraries of copolymers as liquid/solid supports with different compositions, libraries of biodegradable materials for clinical applications, libraries of stationary phases for GC/LC separations, libraries of polymeric reagents or catalysts, libraries of artificial polymeric receptors or molecularly imprinted polymers, and libraries of polymeric biosensors. The opportunities that could arise in the near future from novel applications of polymer libraries are also briefly discussed. 

Molecular imprinted polymers (MIPs) attracted significant attention in the last decade as chiral stationary phases targeted for the separation of selected compounds used as templates during the synthesis of packing material [88]. 

Molecularly imprinted polymer (MIP) type CSPs. Driven by the concept of preparing highly stereoselective synthetic receptors to be used as chiral SOs for the separation of enantiomers. MIP type CSPs have been prepared. These exhibit predetermined... 

To overcome the problem of their limited range of applicability and to extend the spectrum of application other than to the imprint molecule, molecularly imprinted polymer combinatorial libraries for multiple simultaneous chiral separations have been prepared [ 191 ], demonstrating that the ligand cross-reactivities of molecularly imprinted polymers can be beneficially employed for the simultaneous separation of different stereoisomeric structures. 

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