Self-assembly peptide systems

Aggeli, A., Boden N., and Zhang S., "Self-Assembling Peptide Systems in Biology, Medicine and Engineering". Kluwer Academic Publishers, Dordrecht, The Netherlands (2001a). 

Aggeli, Amalia, Neville Boden, and Shuguang Zhang. Self-Assembling Peptide Systems in Biology, Medicine, and Engineering. Boston Kluwer Academic Publishers, 2001. 

D.W. Urry, L. Hayes, C.-X. Luan, D.C. Gowda, D. McPherson, J. Xu, and T. Parker, AT,-Mechanism in the Design of Self-Assembling Structures. In Self-assembling Peptide Systems in... 

Aggeli, A. Boden, N. Zhang, S. Self-Assembling Peptide Systems In Biology, Medicine and Engineering, Kluwer Academic Publishers Dordrechl, Norwell, 2001 pp 364. 

Luo Zhongli and Zhang Shuguang. Designer nanomaterials using chiral self-assembling peptide systems and their emerging benefit for society. Chem. Soc. Rev. 41 no. 13 (2012) 4736-4754. 

Fig. 24 Coiled-coil-based self-assembling peptide system designed by Woolfson s group. A Amino acid sequences of self-assembing fiber (SAF) peptides (SAF-pl, -p2 and -p3). B Concept for a sticky-end assembly process. Complementary charges in companion peptides direct the formation of staggered, parallel heterodimers the resultant sticky-end are also complementary and promote longitudinal association into extranded nanofibers. C Helical wheel representation of coiled-coil conformation. (Adapted from [85])...

There are some unique examples of organic-inorganic hybrids in natural systems. Some kinds of protein possess inorganic components at their interior. Because such bio-originated hybrid structures have discrete size and composition, they can be used for preparation of fine mesoscopic structures. For example, ferritin, which is composed of 24 self-assembled peptide subunits and capable of including iron oxide, is a good candidate to fulfill this demand. Yamashita demonstrated use of a ferritin array for preparation of a mesoscopic nanodot array (Fig. 2.11 ).47 A Langmuir... 

Although bacterial hosts can be useful for protein production, E. coli and other prokaryotic expression systems have some limitations. For example, they are incapable of posttranslational modifications such as glycosylation and as a consequence many eukaryotic proteins produced in prokaryotic expression systems are nonfunctional (Rai and Padh, 2001). However, in the case of most peptides, including self-assembling peptides, such modifications are currently not required. Of course, this limitation may have implications for future... 

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