Self fiber peptides

Ryadnov MG, Woolfson DN. Introducing branches into a self-assembling peptide fiber. Angew Chem Int Ed 2003b 42 3021-3023. 

Alternative to fibers and 2D and 3D woven or nonwoven networks thereof formed as either self-supporting structures or as a hydrogel, it is possible to self-assemble peptides into thin self-assembled monolayers (SAMS) or multilayer structures. Such structures have been reported to act as membranes for controlled diffusion of ions and controlled movement of body fluids and contaminants (Ellis-Behnke et al., 2006, 2007 Holmes et al., 1999). Alternatively, various techniques have been put in place to provide coatings on various substrates ranging from tissue to metals and inorganics, for example, mica (Boden et al., 2002 Haynie, 2005,2007 Haynie and Zhi, 2007 Yoo et al., 2008). 

Self-assembly peptide fibers Mimics specific ECM peptide fibers Reproducible Poor mechanical properties Relatively expensive to produce Degradable... 

SCI in adult rats (Novikov et al. 2002). PHB fibers demonstrated improved neuronal survival in comparison with the implantation of only alginate hydrogel or fibronectin. Novikova et al. demonstrated PHB scaffold seeded with Schwann cells significantly promote spinal cord repair (Novikova et al. 2008). Silk (Uebersax et al. 2007), chitosan (Nomura et al. 2008 Li et al. 2009), self-assembling peptide nanofibers (Guo et al. 2009), and hyaluronic acid (Wang and Spector 2009) are more examples of natural materials that have been examined in spinal cord research. 

SAPNS Self-assembling peptide nano-fiber scaffold... 

Fig. 24 Coiled-coil-based self-assembling peptide system designed by Woolfson s group. A Amino acid sequences of self-assembing fiber (SAF) peptides (SAF-pl, -p2 and -p3). B Concept for a sticky-end assembly process. Complementary charges in companion peptides direct the formation of staggered, parallel heterodimers the resultant sticky-end are also complementary and promote longitudinal association into extranded nanofibers. C Helical wheel representation of coiled-coil conformation. (Adapted from [85])...

Bulut, S., Erkal, T.S., Toksoz, S., Tekinay, A.B., Tekinay, T., Guler, M.O., 2011. Slow release and delivery of antisense oUgonncleotide dmg by self-assembled peptide amphiphile nano-fibers. Biomacromolecules 12, 3007-3014. 

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