Chemical self-assembly

Sessler, J.L. and Jayawickramarajah, J. (2005) Functionalized base-pairs Versatile scaffolds for self-assembly. Chemical Communications, 1939-1949. 

Catenanes have attracted considerable current interest particularly owing to their recently explored potential as molecular-scale devices. The incorporation of a coordination bond into catenane frameworks makes it possible to realize a quick molecular motion, which is somewhat similar to that of well-known magic rings under thermodynamic conditions a catenane framework rapidly arises from two preformed molecular rings. In the following sections, we describe the self-assembly, chemical manipulation, and characterization of several self-assembled catenanes. 

Figure 4-5 PNA-encoded self-assembling chemical arrays, (a) Each small molecule was labeled with a PNA tag as well as a fluorophore. (b) The tagged molecules were hybridized with their complementary sequences on a decoding array, (c) Incubation of the tagged molecule library with a protein sample generated a protein-small molecule conjugate, which could be separated by using size-exclusion chromatography. Structural information on the bound small molecule was decoded by the decoding array.

Figure 4-6 DNA-encoded self-assembling chemical libraries.

Melkko, S., Scheuermann, J., Dumelin, C. E., Neri, D. (2004). Encoded self-assembling chemical libraries. Nat. Biotechnol, 22, 568-574. 

A class of colloidal assemblies that evokes interest in its synthesis approaches and physicochemical properties are hollow spheres or capsules [21], Hollow spheres are discrete volume closures that have a well-defined boundary separating the interior from the bulk external environment [8,22], Popular routes for the synthesis of hollow spheres can be categorized into self-assembly, chemical reactions, sequential electrostatic assembly, and interfacial stabilization approaches [9,13,23 0],... 

Suzuki M, Hanabusa K. Polymer organogelators that make supramolecular organogels through physical cross-linking and self-assembly. Chemical Society Reviews. 2010 39(2) 455—463. 

This concept has been utilized by Neri s group in synthesizing DNA-recorded libraries called encoded self-assembling chemical (ESAC) libraries, and by Hamilton s group in constructing a library of bidentate fragments for binding to streptavidin. As a matter of fact, these libraries are not synthesized, but assembled by combinatorial DNA hybridization. 

DNA-Recorded Synthesis Assisted Libraries Encoded Self-assembly chemical library... 

The focus of this article is based on experimental results obtained and reported by members of our research group in recent years, on the use of self-assembled chemical systems, particularly microemulsions, in some areas involved in modem petroleum industry [21-39]. After initial presentation on some historical aspects that led to the development of this work, we aim to cover the following main subject areas ... 

Zeng, Rand Zimmerman, S.C. (1997) Dendrimers in supramolecular chemistry from molecular recognition to self-assembly. Chemical Reviews, 97,1681-1712. 

Another type of EDOT Cgo-derivatives has been prepared (see Figure 13.28) with the surprising ability to form self-assembled, chemically adsorbed monolayers on gold surfaces. Electro-oxidation lead to desorption of the SAM, traced by the disappearance of the fullerene related peaks. 

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