Self assembled monolayers chemical transformations

Chemical transformations in self-assembled monolayers were studied mainly with alkyl-siloxane films on oxidized silica, probably because these layers are more stable than... 

It is known, however, that isothiocyanates on their own can form stable self-assembled monolayers on gold (Section V.E), and amine-terminated monolayers were reported to show unusually low reactivity towards electrophilic reagents329,330. It is therefore possible that the observed immobilization of eosin is due not to reaction with amino groups, but to either insertion of the eosin isothiocyanate into a disordered layer of cysteamine, or even replacement of cysteamine monolayer with the molecules of S=C=N—eosin. Because the experimental data on reactions in gold-thiol monolayers are scarce, chemical transformations described in this section should be interpreted with some caution. 

Nevertheless, the authors have reported so far a large range of applications on lipid and membrane systems of sizes comparable to those studied using MARTINI, including spontaneous vesicle self-assembly, monolayer collapse, vesicle to micelle transformation and membrane fusion. The SDK model thus represents a powerful and promising approach to investigate finely tuned chemical properties of large lipid assemblies when cheaper but less accurate CG models turn out to be unsuccessful. 

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