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Encoded self-assembling chemical libraries

Figure 4-6 DNA-encoded self-assembling chemical libraries. Figure 4-6 DNA-encoded self-assembling chemical libraries.
Melkko, S., Scheuermann, J., Dumelin, C. E., Neri, D. (2004). Encoded self-assembling chemical libraries. Nat. Biotechnol, 22, 568-574. [Pg.79]

DNA-Recorded Synthesis Assisted Libraries Encoded Self-assembly chemical library... [Pg.262]

Figure 4-5 PNA-encoded self-assembling chemical arrays, (a) Each small molecule was labeled with a PNA tag as well as a fluorophore. (b) The tagged molecules were hybridized with their complementary sequences on a decoding array, (c) Incubation of the tagged molecule library with a protein sample generated a protein-small molecule conjugate, which could be separated by using size-exclusion chromatography. Structural information on the bound small molecule was decoded by the decoding array. Figure 4-5 PNA-encoded self-assembling chemical arrays, (a) Each small molecule was labeled with a PNA tag as well as a fluorophore. (b) The tagged molecules were hybridized with their complementary sequences on a decoding array, (c) Incubation of the tagged molecule library with a protein sample generated a protein-small molecule conjugate, which could be separated by using size-exclusion chromatography. Structural information on the bound small molecule was decoded by the decoding array.
This concept has been utilized by Neri s group in synthesizing DNA-recorded libraries called encoded self-assembling chemical (ESAC) libraries, and by Hamilton s group in constructing a library of bidentate fragments for binding to streptavidin. As a matter of fact, these libraries are not synthesized, but assembled by combinatorial DNA hybridization. [Pg.292]


See other pages where Encoded self-assembling chemical libraries is mentioned: [Pg.266]    [Pg.275]    [Pg.266]    [Pg.275]    [Pg.1275]    [Pg.3419]    [Pg.66]    [Pg.3418]    [Pg.1426]    [Pg.1427]   
See also in sourсe #XX -- [ Pg.66 , Pg.71 , Pg.74 ]




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