Searching the Inventory

To request a search of the confidential Inventory, the requestor must demonstrate that it has a bona fide intent to manufacture or import the chemical for commercial purposes. Because this information is only available to potential manufacturers and importers, downstream processors and users cannot request a search, and must rely on suppliers for compliance information. 

To establish the bona fide intent, the potential manufacturer or importer must supply the following information to the EPA in a submittal usually referred to as a bona fide notice or letter  

A similar request may be made under 40 C.ER. 721.11 for determining the applicability of a significant new use rule. See Chapter 12. Significant New Use Rules. 

If an importer cannot provide the chemical identity information because the identity is claimed as confidential, it can request that the foreign supplier send the information directly to EPA, referencing the importer s notice. If the information is not received within thirty days after receipt of the importer s notice, EPA will consider the bona fide notice incomplete. If the chemical substance is manufactured with a reactant that has a specific chemical identity claimed as confidential by the suppHer, the manufacturer must provide the best chemical identity information it has and must have the suppHer of the chemical reactant provide directly to EPA a letter of support with the specific chemical identity of the reactant, referencing the manufactmer s notice. If the information is not received within thirty days after receipt of the importer s notice, EPA will consider the bona fide notice incomplete.  

The regulations require the EPA to determine if the submittal adequately documents a bona fide intent to manufacture or import, and if so the EPA must conduct the search of the confidential Inventory and respond within thirty days of receipt of a complete submission. EPA will also notily the original submitter of the Inventory submission that another party has 

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The civil and criminal penalties for making, importing, or processing a chemical that is not on the Inventory can be severe, not to mention the potential for business disruption that could result if a company finds that one of its products should be on the Inventory but is not there. Therefore searching the Inventory to determine whether chemicals that will be manufactured, imported, or processed are fisted is a central function in TSCA compliance. This task is greatly complicated by the fact that there is also a confidential Inventory, composed of chemicals whose identities are not released to the public. 

Id.-, for the Inventory description see the EPA Substance Registry Services Web site at http // iaspub.epa.gov/sor internet/registry/substreg/searchandretrieve/searchbylist/search.do and search the Inventory for CAS 25190-06-1. 

An alternative to relying on the supplier s warranty is to ask EPA to search the Inventory, including the confidential portion, by establishing a bona fide intent to import the chemical substance.The requirements to establish a bona fide intent to import a chemical substance are the same as the requirements... 

There are many years between the search for a hit, development of a lead, and then its launch as a drug. Thus, the inventory of currently marketed dmgs gives only an imperfect view of the synthetic challenges that medicinal chemists have to face. For this reason, this chapter ends with exemples of fluorinated moieties recently introduced in medicinal chemistry. These functional structural patterns, which are present on new drugs or on molecules at an early stage of development, will possibly have a strong impact in medicinal chemistry in the future. 

A generic solution that has been proposed for these issues is to systematically trace the route between a known point inside our network and the victim/source host. We could then retrieve the location of the last router or switch, than is fixed and known in the inventory, and thus strongly reduce the physical search space for the machine. 

The non-confidential AICS can be accessed on-line via the NICNAS Web site. Alternatively, a request to search the AICS can be made to NICNAS. Furthermore, a search of the confidential section of the AICS can be requested but only through this mechanism. The AICS is also available on the Chemical Abstract Services Chemlist database or National Chemical Inventories (NCI) [4]. 

The chemicals stored in the inventory can be searched by exact structure, substructure, or similarity [26], Similarity searching aims at retrieving compounds that are similar to a query compound by one or more measures of similarity. A set of structural features of the target molecule is compared with those of each chemical in the database, generating a similarity measure by a chosen metric such as the Tanimoto coefficient [27]. More details about chemical similarity are given below in relation to the chemical similarity tool. 

New chemical substances are all those not on the Domestic Substances List (DSL), which is a list of substances in commerce in Canada at >100 kg a from 1 January 1984 to 31 December 1986. If a new substance is on the Non-Domestic Substances List (NDSL), the information required for the notification is considerably less than for a standard notification. The NDSL, which is the 1985 US TSCA Inventory (as amended) minus the substances on the DSL, attempts to take account of established substances which did not happen to be sold in Canada during the period for inclusion in the DSL. The first DSL [33] and NDSL [34] were both publish in the Canada Gazette on 26 January 1991, and these inventories will be updated and corrected periodically when necessary. Most polymers are represented on the inventories in terms of the starting materials from which they are manufactured, and products of biotechnology will be included subsequently if necessary when their regulatory controls have been finalised. The DSL and NDSL contain confidential sections, which can be searched by Environment Canada if a bona fide intent to manufacture or import is established by submitting specified data. 

The Chemical Information System (CIS) is used for chemical container tracking (inventory) and MSDS access. The system data is updated daily. Each container is bar-coded either by the JIT vendor, the laboratory owner, or the chemical inventory team. Every employee at SNL can view the data and perform searches. The bar-code number on each container allows access to information about the chemical name, location, quantity, NFPA codes, SARA codes, CAS number, specific gravity or density, and corresponding MSDS, synonyms mixture ingredients and percentage vendor information dates in and out and chemical owner. Information is obtained from the JIT and other vendors, lab owners, and the Chemical Inventory Team. Vendors supplying bulk quantities of chemicals (diesel fuel, liquid nitrogen, etc.) notify the CIS Team when they fill tanks. 

Zinc oxide (ZnO), zinc-64 depleted is now on the Inventory, through the PMN process. See http //iaspub.epa.gov/sor internet/registry/substreg/searchandretrieve/searchbyUst/search. do synId=8367968cdisplaySynonym=. 

The official version is available for purchase at http //www.ntis.gov. Use the product search function to locate the Inventory. The public Inventory can be partially accessed without charge at the EPA s Substance Registry Service at http //iaspub.epa.gov/sorjnternet/registry/ substreg/home/overview/home.do. Commercial services also sell the Inventory, such as that maintained by the Chemical Abstract Service at http //www.cas.org. 

A disadvantage of filing a PMN is that any other manufacturer or importer may make or import the polymer without going through the time consuming PMN process, and in essence may take a free ride on the work done to shepherd the chemical through the PMN process. Even if the substance is listed on the confidential Inventory, anyone who has actual plans to manufacture or import the chemical may submit a request to the EPA to search the confidential Inventory to see if the substance is listed there. ... 

Step 3. The MRC shaU search the publicly available TSCA Inventory and determine if the chemical substance is listed. If the substance is not on the publicly available TSCA Inventory, the MRC shall determine based on the chemistry of the substance and the generic chemical names on the confidential Inventory whether it is possible that the substance is on the confidential Inventory. If it may be on the confidential Inventory, the MRC shall confer with the requester and decide if it is appropriate to submit a bona fide letter to request confirmation from the EPA about the Inventory status of the substance. 

Either the inventory analysis or the environmental profile can be used to identify aspects in need of improvement. Once the processes and substances with the most significant contributions to the environmental profile have been identified, the search for more environmentally-friendly alternatives can start. These alternatives then have to be evaluated individually by experts within, for example marketing, processing and finance and then compared with each other to establish the most feasible alternative. 

In case that no MSDS is available, there exists the possibility to search the required information in the databank of the European Chemicals Agency (ECHA). In the C L-Inventory, the CAS and/or EINECS numbers, the corresponding classi cation, required labels and the corresponding H (hazard) and the P (precautionary) statements, and the CHS pictograms of all chemicals registered in the EU can be found. However, this ECHA databank is of help only for orientation, as, for example, there exist for Orange Oil sweet CAS No. 8028-48-6 a total of 56 entries. 

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