Sciatic Neuropathy

Soft-tissue disorders arising from the posterior hip essentially include traumatic injury at the insertion of the hamstring muscles, sciatic neuropathies and ischiogluteal bursitis. The coexisting involvement of the hamstrings insertion at the ischium and the adjacent sciatic nerve is a common condition observed in athletes who present with pain near the ischial tuberosity. It is commonly referred to as... 

The chronic neurotoxic effects of methylmercury in animals are similar to those seen after intermediate exposure. Mice administered methylmercuric chloride in the diet for 2 years at approximately 0.6 mg Hg/kg/day showed posterior paralysis and sensory neuropathy, characterized by cerebral and cerebellar necrosis, as well as degeneration of spinal dorsal nerve roots and the sciatic nerve (Hirano et al. 1986 Mitsumori et al. 1990). Cats fed contaminated fish or contaminated fish and methylmercury at doses as low as 0.046 mg Hg/kg/day for 2 years exhibited neurobehavioral toxic signs, including mild impairment of motor activity and diminished sensitivity to pain (Charbonneau et al. 1976). These effects began after 60 weeks of exposure but did not progress during the remainder of the 2 years of exposure. 

Nerve conduction in organophosphorus-induced delayed neuropathy (OPIDN) was studied using adult white leghorn hen.s treated with ui-2-t -cresyl pho.sphate or di- -butyl-2,2-dichlorovinyi phosphate (Robertson et al, 1987). Refractoriness was decreased in the tibial nerve but it was incrca.sed in the sciatic nene, and the. strength-duration threshold was elevated for both nerves. However, it is not known how these changes are related to the mechanism of OPIDN,... 

Escudero. M. A., and Vilanova, E. (1997). Puriftcaiioti and characterization of naturally soluble neuropathy target esterase from chicken sciatic nerve by HPLC and Western blot. J. Neuroche.m. 69, 1-8. 

ONO-2235 (9) is the predominant E,E geometric isomer resulting from condensation of a-methylcinnamaldehyde with rhodanine-N-acetic acid and not the E,Z isomer as incorrectly shown in reference 83. This agent is a potent inhibitor of REAR and given orally for two weeks markedly reduced sorbitol levels in rat sciatic nerve and improved MNCV and has completed three months clinical evaluation in neuropathy patients. ... 

Nervous system In a retrospective study to analyse the incidence of peripheral neuropathy in 157 patients with continuous sciatic nerve block in the popliteal fossa, three patients with an associated common superficial peroneal and sural nerve injury were identified via clinical and electromyographical studies [21 ]. In 44% percent of the patients US guidance was combined with a nerve stimulator technique. The authors conclude that methodological bias or technical problems (lateral vs posterior approach, US guidance) may account for the higher (1.9%) than average (0-0.5%) rate of peripheral neuropathy. It is of note that anatomically the common superficial peroneal and sural nerves were more affected than the tibial nerve, possibly due to their superficial location. 

Primary non-Hodgkin lymphomas affecting peripheral nerves are very rare. Most involve the sciatic nerve and are the result of direct spread from adjacent tumors (Roncaroli et al. 1997). Peripheral neuropathy may also be appreciated in the absence... 

---