Bone tissue engineering scaffolds

Keywords Bioabsorbable composite scaffold Bone tissue engineering ... 

Ordered mesoporous silica have already been studied as carriers for drug delivery [1,2] recently, their use has also been proposed in bone tissue engineering [3,4], in combination with bioactive glass-ceramic scaffolds [5,6]. The kinetics of ibuprofen release in SBF [7] from MCM-41 silica with similar pore diameter has shown puzzling discontinuities [3,6,8] aim of the present work is to assess whether these anomalies may be related to structural changes in the MCM-41 mesoporous spheres under the adopted conditions. 

Li Z, Ramay HR, Hauch KD et al (2005) Chitosan-alginate hybrid scaffolds for bone tissue engineering. Biomaterials 26 3919-3928... 

Yilgor, P., Sousa, R.A., Reis, R.L., Hasirci, N. and Hasird, V. (2008) 3D plotted PCL scaffolds for stem cell based bone tissue engineering. Macromolecular Symposia, 269, 92-99. 

Zang et al. developed a peptide-based polyurethane scaffold for tissue engineering. LDI was reacted with glycerol and upon reaction with water produced a porous sponge due to liberation of CO2. Initial cell growth studies with rabbit bone marrow stromal cells showed that the polymer supported cell growth. 

As well as being used as a scaffold for tissue engineering, Hutchens et al. [64] described the creation of a calcium-deficient hydroxyapatite, the main mineral component of bone. Calcium phosphate particles were precipitated in BC by consecutive incubation of calcium chloride and sodium phosphate solutions. Initial tests with osteoblasts in the in vitro evaluation showed that solid fusion between the material and the bone tissue is possible. Hence, this material is a good candidate for use as a therapeutic implant to regenerate bone and heal osseous damage. 

Kim, H.J., Kim, U.J., Vunjak-Novakovic, G., Min, B.H., and Kaplan, D.L. "Influence of macro-porous protein scaffolds on bone tissue engineering from bone marrow stem cells". Biomaterials 26(21), 4442-4452 (2005a). 

Meinel, L., Karageorgiou, V., Fajardo, R., Snyder, B., Shinde-Patil, V., Zichner, L., Kaplan, D., Langer, R., and Vunjak-Novakovic, G. "Bone tissue engineering using human mesenchymal stem cells Effects of scaffold material and medium flow". Ann. Biorned. Eng. 32(1), 112-122 (2004b). 

Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27(18) 3413—3431... 

Kretlow JD, Mikos AG (2007) Review mineralization of synthetic polymer scaffolds for bone tissue engineering. Tissue Eng 13(5) 927—938... 

H. Yoshimoto, Y.M. Shin, H. Terai, J.P. Vacanti. 2003. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials, 24. pp. 2077. 

Bokhari, M. Birch, M. Akay, G. Polyhipe polymer a novel scaffold for in vitro bone tissue engineering. Adv. Exp. Med. Biol. 2003, 534, 247-254. 

Table 2 Desirable qualities of a bone tissue-engineering scaffold [56]...

Xie F et al (2006) Effect of shearing on formation of silk fibers from regenerated Bombyx mori silk fibroin aqueous solution. Int J Biol Macromol 38(3-5) 284-288 Li C et al (2006) Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 27(16) 3115-3124... 

Jose MV et al (2010) Aligned bioactive multi-component nanofibrous nanocomposite scaffolds for bone tissue engineering. Macromol Biosci 10(4) 433 144... 

Li X et al (2008) Coating electrospun poly(epsilon-caprolactone) fibers with gelatin and calcium phosphate and their use as biomimetic scaffolds for bone tissue engineering. Langmuir 24(24) 14145-14150... 

Ngiam M et al (2009) The fabrication of nano-hydroxyapatite on PLGA and PLGA/collagen nanofibrous composite scaffolds and their effects in osteoblastic behavior for bone tissue engineering. Bone 45(1) 4—16... 

---