SAS Institute

EMC POLYPHENIX FRANCE TREDI TESSENDERLO CHEMIE SA INSTITUT FRANCAIS DU PETROLE... 

SAS/ETS, Statistical Analysis System Econometrics and Time Series. SAS Institute, Cary, North Carolina, 1983. 

SAS/BASE is a registered trademark or trademark of SAS Institute Inc. in the USA and other countries. Indicates USA registration. 

SAS/IML (Interactive Matrix Language) Software User and Reference Manual. Version 6,1 st Ed., SAS Institute Inc., Cary, NC, 1990. 

SAS users groups are user-based communities supported by SAS Institute that are organized by geographical or industrial areas. These users groups typically have annual meetings where you can go to leam and to network with fellow SAS programmers. 

The correct bibliographic citation for this manual is as follows Shostak, Jack. 2005. 4S Programming in the Pharmaceutical Industry. Cary, NC SAS Institute Inc. 

For a hard-copy book No part of this publication may be reproduced, stored in transmitted, in any form or by any means, electronic, mechanical, photocopying, prior written permission of the publisher, SAS Institute Inc. 

U.S. Government Restricted Rights Notice Use, duplication, or disclosure of this software and related documentation by the U.S. government is subject to the Agreement with SAS Institute and the restrictions set forth in FAR 52.227-19, Commercial Computer Software-Restricted Rights (June 1987). 

SAS Institute Inc., SAS Campus Drive, Cary, North Carolina 27513. 

Statistical Analysis. Analysis of variance (ANOVA) of toxicity data was conducted using SAS/STAT software (version 8.2 SAS Institute, Cary, NC). All toxicity data were transformed (square root, log, or rank) before ANOVA. Comparisons among multiple treatment means were made by Fisher s LSD procedure, and differences between individual treatments and controls were determined by one-tailed Dunnett s or Wilcoxon tests. Statements of statistical significance refer to a probability of type 1 error of 5% or less (p s 0.05). Median lethal concentrations (LCjq) were determined by the Trimmed Spearman-Karber method using TOXSTAT software (version 3.5 Lincoln Software Associates, Bisbee, AZ). 

The goal of the prioritization scheme is to design the scores so that the overall worst looking compounds are de-emphasized and the best looking compounds are moved toward the top of the list. Thus, it is important to ensure that the best and the worst compounds are clearly separated and that the vast bulk of the population is in the middle. The normal distribution is ideally suited for this and thus it is advantageous to transform our component scores into a normal-like distribution. Enterprise Miner from SAS Institute was used to do this as it has a maximize normality transformation built into it. 

Littel RC, Milliken GA, Stroup WW, Wolfinger RD. 1996. SAS system for mixed models. Cary (NC) SAS Institute Inc. 

Smith GD and Eggar M (1997) Letter to the Editor The Lancet, 350, 1182 Stokes ME, Davis CS and Koch GG (1995) Categorical Data Analysis Using the SAS System Cary, NC SAS Institute Inc. 

Analysis of variance (ANOVA) analyses were performed using the general statistical package StatView 5.01 (SAS Institute, Cary, NC, USA). The ANOVAs were calculated as repeated-measures ANOVAs with wells as within factor for phase 1 and with plates as within factor for subsequent phases. Specialized statistics, such as comparison of fits of different calibration curves, were calculated in MATLAB 5.1 (MathWorks, Natick, MA, USA) using custom routines. 

The analysis of variance (ANOVA) gives information on the significant effects. Data were analyzed using the general linear model (GLM) procedure from the Statistical Analysis System (SAS Institute, Cary, NC). A discussion and explanation of the statistics involved are given by Davies [19]. 

Perform statistical analysis utilizing repeated measures ANOVA (JMP software, Version 5 from SAS Institute, Cary, NC) to evaluate the treatment effects on tumor growth. Compare tumor weight measurements between treatment groups utilizing one-way ANOVA. 

SAS Transport File Format. We are able to archive data sets in SAS XPORT transport format, also called version 5 SAS transport format. This is an open, published file format developed by SAS Institute. For additional information, see the SAS Institute s Standards for Electronic Submissions and SAS XPORT transport format Web site. 

SAS Institute (1988), SAS/STAT Users Guide, Release 6.03 Ed., SAS Institute, Cary, NC. 

Two sets of SSDs were created based on ICE extrapolations from ECOSAR fish values (assuming fish = fathead minnow) 1) all 27 predicted ICE species, excluding ECOSAR values and 2) the 27 ICE species plus ECOSAR hsh, daphnids, and algae. SSDs were created using a log-normal distribution (SAS Institute 2002). Figure 3.3 illustrates the SSDs for DCA and NP with and without ECOSAR species, and Figure 3.4 provides the distributions for PCP and LAS. The predicted hazard... 

SAS Institute. 2002. Statistical analysis software [computer program]. Version 8. Cary (NC) SAS. 

---