SARS replication

Olsen DB (2006) Potent nucleoside inhibitors of HCV RNA replication SAR and other lessons learned. In 17th international roundtable on nucleosides, nucleotides and nucleic acids, Bern, Switzerland... 

Sainz B Ir, Mossel EC, Peters CJ, Garry RF (2004) Interferon-beta and interferon-gamma syner-gistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Virology 329 11-17... 

Hamasaki K, Nakao K, Matsumoto K, Ichikawa T, Ishikawa H, Eguchi K (2003) Short interfering RNA-directed inhibition of hepatitis B vims replication. EEBS Lett 543 51-54 He ML, Zheng B, Peng Y, Peiris IS, Poon LL, Yuen KY, Lin MC, Kung HP, Guan Y (2003) Inhibition of SARS-associated coronavims infection and replication by RNA interference. JAMA 290 2665-2666... 

H. W. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 2003, 361, 2045-2046. 

P. A. Methods and Compositions for Inhibiting SARS-Related Coronavirus Replication by Using Inhibitors of SARS-Related Coronavirus 3C Proteinase. World Patent W02004093860, November 11, 2004. 

McAuliffe J, Vogel L, Roberts A, et al. Replication of SARS coronavirus administered into the respiratory tract of African green, rhesus and cynomolgus monkeys. Virology. 2004 5 ... 

The majority of RSV inhibitors that have emerged from cell-based virus replication assays have been determined to be inhibitors of the virus-host fusion process. The discovery and basic SAR associated with these compounds will be described followed by a discussion of their mode of action that, quite remarkably given the structural diversity, appears to converge on interfering with the formation and/or function of the RSV F protein six-helix bundle complex. 

This initial lead showed potent binding affinity to CCR5 (IC50 35 nM), but only weak, micromolar activity in a PBMC viral replication assay, with a dose analog also showing very low oral bioavaUability in rat [40, 41]. Development of SAR through... 

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