SARS coronavirus

Lee TW, Chemey MM, Huitema C, Liu J, James KE, Powers JC, Eltis LD, James MN (2005) Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-fike aza-peptide epoxide. J Mol Biol 353 1137-1151 Liang PH (2006) Characterization and inhibition of SARS-coronavirus main protease. Curr Top Med Chem 6 361-376... 

Lu A, Zhang H, Zhang X, Wang H, Hu Q, Shen L, Schaffhausen BS, Hou W, Li L (2004) Attenuation of SARS coronavirus by a short hairpin RNA expression plasmid targeting RNA-dependent RNA polymerase, Virol 324 84-89... 

HCV 3D polymerase NS5B SARS Coronavirus main protease A1-antitrypsin aggregation... 

Lin CW, Tsai FJ, Tsai CH, Lai CC, Wan L, Ho TY, Hsieh CC, Chao PD. (2005) Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Res 68 36-42. 

Sutton, G., et al. (2004). The nsp9 replicase protein of SARS-coronavirus, structure and functional insights. Structure (Camb) 12,341-353. 

Zhou et al. [175] described the determination of severe acute respiratory syndrome (SARS) coronavirus by a microfluidic chip system. The unit included an LIF microfluidic chip analyzer, a glass microchip for both PCR and capillary electrophoresis, a chip thermal cycler based on dual Peltier thermoelectric elements, a reverse transcription-polymerase chain reaction (RT-PCR) SARS diagnostic kit, and a DNA electrophoretic sizing kit. According to the authors, the system allowed efficient DNA amplification of the SARS coronavirus followed by electrophoretic sizing and detection on the same chip. 

FIGURE 9.3 Early hits for inhibition of SARS-coronavirus Mpro2 3... 

Kuhn, J. H., Li, W., Choe, H., et al. 2004. Angiotensin-converting enzyme 2 a functional receptor for SARS coronavirus. Cell Mol Life Sci 61 2738-2743. 

Graziano, V. et al. 2006 Enzymatic activity of the SARS coronavirus main proteinase dimer. FEBS Lett. 580, 2577-2583. 

FIGURE 3.25 SARS. Coronavirus antigen-positive pneumocytes and macrophages in the lung of a SARS case. (Immunoalkaline phosphatase with naphthol fast red substrate and hematoxylin counterstain original magnification x63.)... 

McAuliffe J, Vogel L, Roberts A, et al. Replication of SARS coronavirus administered into the respiratory tract of African green, rhesus and cynomolgus monkeys. Virology. 2004 5 ... 

Roberts A, Vogel L, Guarner J, et al. SARS coronavirus infection of golden Syrian hamsters. J Virol. 2005 79 503-511. 

Traggiai, E., Becker, S., Subbarao, K., Kolesnikova, L., Uematsu, Y., Gismondo, M.R., Murphy, B.R., Rappuoli, R., Lanzavecchia, A. An efficient method to make human monoclonal antibodies from memory B cells potent neutralization of SARS coronavirus. Nat. Med. 2004, 10, 871-875. 

Jenwitheesuk E, Samudrala R. Identilying inhibitors of the SARS coronavirus proteinase. Bioorg Med Chem Lett 2003 13(22) 3989-3992. 

Moser, M. J. Prudent, J. R. SARS coronavirus-specific fluorescent primers, and their use in real-time RT-PCR assays designed for detecting SARS virus. PCT Int. Appl. WO 2005081776, 2005 Chem. Abstr. 2005,143, 280470. 

Scientists at the J. Craig Venter Institute are studying the genome of the SARS coronavirus, which causes severe acute respiratory syndrome, in humans and animals in an effort to determine how the virus crosses the species barrier. 

Snijder, E.J., Bredenbeek, P.J., Dobbe, J.C., Thiel, V., Ziebuhr, J., Poon, L.L., Guan, Y, Rozanov, M., Spaan, W.J. and Gorbalenya, A.E., Unique and conserved featmes of genome and proteome of SARS-coronavirus, an early spUt-off from the coronavirns group 2 lineage. J. Mol Biol, 331, 991-1004 (2003). 

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