Ryanodine receptors, FKBP12-binding

Ryanodine Receptor. Figure 1 Three-dimensional architecture of the RyR1 by cryo-electron microscopy, (a), top view (from the T-tubule) (b), bottom view (from the SR lumen) (c), side view (parallel to the SR membrane). The binding sites of FKBP12, apo-CaM and Ca -CaM are indicated in the side view. Courtesy of Dr. M. Samso (modified from Samso etal. (2005) Nat Struct Mol Biol 12 539-544). 

Aizawa, Y., Ueda, K., Komura, S., Washizuka, T., Chinushi, M., Inagaki, N., Matsumoto, Y., Hayashi, T. and M. Takahashi, Nakano, N., Yasunami, M., Kimura, A., and Hiraoka, M. (2005). A Novel Mutation in FKBP12.6 Binding Region of the Human Cardiac Ryanodine Receptor Gene (R2401H) in a Japanese Patient with Catecholaminergic Polymorphic Ventricular Tachycardia. Int J Cardiol 99(2) 343-5. 

Prestle, J., Janssen, P. M., Janssen, A. P., Zeitz, O., Lehnart, S. E., Bruce, L., Smith, G. L., and Hasenfuss, G. (2001). Overexpression of FK506-Binding Protein FKBP12.6 in Cardiomyocytes Reduces Ryanodine Receptor-Mediated Ca(2+) Leak from the Sarcoplasmic Reticulum and Increases Contractility. Circ Res 88(2) 188-94. 

Xiao, B., Sutherland, C., Walsh, M.P., et al. 2004, Protein kinase A phosphorylation at serine-2808 of the cardiac Ca -release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6). Circ Res, 94(4), pp 487-95. 

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