Rynaxypyr A New Anthranilic Diamide Insecticide Acting at the Ryanodine Receptor

Rynaxypyr A New Anthranilic Diamide Insecticide Acting at the Ryanodine Receptor 

George P. Lahm, Thomas M. Stevenson, Thomas P. Selby, John H. Freudenberger, Christine M. Dubas, Ben K. Smith, Daniel Cordova, Lindsey Flexner, 

Christopher E. dark, Cheryl A. Beilin,]. Cary Flollingshaus 

These compounds were tested against a series of Lepidoptera imder standard laboratory procedures. Activity on diamondback moth (PluteUa xylostdla, Px), fall armyworm (Spodoptera frugiperda, Sf), and tobacco budworm (Heliothis virescens, Hv) was evaluated. Insecticidal potency is reported as the LCjq in ppm. Comparison of the insecticidal activity for compounds D1-D3 identifies several key structural features of importance (Table 1). Our initial lead compoimd D1 was effective on the species S/and Px with LCjq values of 68.9 and 16.8, respectively, but with no activity on Hv. Incorporation of a 2-methyl group on the benzamide, 

The striking data of Table I come from the comparison of the 6-methyl and 

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