Rollinia

Kuo R-Y, Chang F-R, Chen C-Y, Teng C-M, Yen H-F, Wu Y-C (2001) Antiplatelet Activity of N-Methoxycarbonyl Aporphines from Rollinia mucosa. Phytochemistry 57 421... 

Rolliniastatin-1 (tetrahydrofuran acetogenin) Rollinia sylvatica (Annonaceae) ETC - NADH-UQOR complex I (0.3nM InM)... 

Squamocin Annona reticulata [seed], Rollinia ETC - NADH-UQOR... 

From the dichloromethane extract of the stems of Rollinia ulei (Annonaceae), three aporphine alkaloids were isolated as the principles responsible for the inhibitory activity on yeast recombinant CD45 tyrosine phosphatase. The most potent alkaloid was nomuciferine (51), with an IC5o=5.3 pM[148]. 

Rolliniastatin-1 was isolated in 1987 from Rollinia mucosa (62), and since then has been found in several species of Annonaceae (4a-b). Koert reported the total synthesis of ew-rolliniastatin-1 110 from L-glutamic acid. The strategy is a sequential synthesis, using as a key step the diastereoselective copper catalyzed Grignard addition on aldehydes (Fig. 12). 

No. Compound name Annona muricata A reticulata A. atemoya Rollinia mucosa A. montana A. cherimola... 

Annonin I (Squamocin) Asimicin Rolliniastatin 1 Rolliniastatin 2 Bullatacin l-srHeell C37H66O7 622.93 622.93 wax 81 -83 wax 73-76 cryst. 69-70 Annona squamosa, Uvaria narum Annona squamosa, Asimina triloba, Rollinia mucosa 120298-30-8 102989-24-2 111056-97-4 121917-13-3 123123-32-0... 

Epoxyrollins A and B were isolated from Rollinia Ulei as an inseparable mixture, and it was reported that they contained a mono epoxy ring and a y-lactone. Tandem mass spectrometry was used to arrive at the structures 131 and 132 to epoxyrollins A and... 

A series of acetate-derived compounds have been reported from plants of the family Annonaceae (Annona cherimolia, A. muricata, A. squamosa, and oth r Annona species Asim-ina triloba, pawpaw Goniothalamus giganteus , and several Rollinia and Uvaria species) (Fig. 5.20) (Alkofahi et al., 1989 Lieb et al., 1990 Nahrstedt, 1985 Rupprecht et al., 1986). Most of these compounds exhibit potent antimicrobial, antiparasitic, cytotoxic, and antitumor activity (Bories et al., 1991). For example, asimicin (36), from the bark of Asimina triloba, is extremely cytotoxic (ED50 <10 p-/ml with several cell cultures) fractionation of the plant material was monitored by the brine shrimp bioassay (Alkofahi et al., 1989). This compound also is toxic to the striped cucumber beetle, Mexican bean beetle, mosquito larvae, blowfly larvae, melon aphid, two spotted spider mite, and the free-living nematode, Caenorabditis elegans (Rupprecht et al., 1986). 

---