Goniothalamus giganteus

Lu Z, Yan Z, McLaughlin JL. Gigantransenins A, B, and C, novel mono-THF acetogenins bearing trans-double bonds, from Goniothalamus giganteus (Annonaceae). Tetrahedron Lett 1996 37 5449-5452. 

Feras QA, Yan Z, Lingling R, McLaughlin JL. Mono-tetrahydrofuran acetogenins from Goniothalamus giganteus. Phytochemistry 1998 49 761-768. 

Alali, F.Q., Zhang, Y., Rogers, L.L., and McLaughlin, J.L. Unusual Annonaceous acetogenins from Goniothalamus giganteus. Tetrahedron, 54, 5833, 1998b. 

Annomontacin Goniothalamus giganteus (Annonaceae) ETC -NADH-UQOR... 

In the same way, gonionenin 168, isolated from Goniothalamus giganteus (79), when treated under the same reaction conditions (m-CPBA, and then perchloric acid), led to a 1 1 mixture of unknown acetogenins trans -cyclogonionenin 169 and c/s-cyclogonionenin 170 (Fig. 30). 

Altholactone (933), an unusual cw-fiised tetrahydrofuran-2-pyrone independently isolated from an unnamed Polyalthia species as well as from Goniothalamus giganteus, is of synthetic interest due to its activity against P388 leukemia (in vivo) as well as its in vitro... 

A series of acetate-derived compounds have been reported from plants of the family Annonaceae (Annona cherimolia, A. muricata, A. squamosa, and oth r Annona species Asim-ina triloba, pawpaw Goniothalamus giganteus , and several Rollinia and Uvaria species) (Fig. 5.20) (Alkofahi et al., 1989 Lieb et al., 1990 Nahrstedt, 1985 Rupprecht et al., 1986). Most of these compounds exhibit potent antimicrobial, antiparasitic, cytotoxic, and antitumor activity (Bories et al., 1991). For example, asimicin (36), from the bark of Asimina triloba, is extremely cytotoxic (ED50 <10 p-/ml with several cell cultures) fractionation of the plant material was monitored by the brine shrimp bioassay (Alkofahi et al., 1989). This compound also is toxic to the striped cucumber beetle, Mexican bean beetle, mosquito larvae, blowfly larvae, melon aphid, two spotted spider mite, and the free-living nematode, Caenorabditis elegans (Rupprecht et al., 1986). 

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