Annona muricata

Hasrat JA, De Bruyne T, De Backer JP, Vauquelin G, Vlietinck AJ. Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats unexploited antidepressive (lead) products. J Pharm Pharmacol 1997 49 1145-1149. 

Treatment of an alkali-soluble xyloglucan from the seed of Annona muricata with cellulase liberated tetra- and penta-saccharides, together with D-glucose, cellobiose, and a small proportion of a D-xylosylcellobiose.25 From the molar amounts of these products, it may be postulated that the... 

Annona muricata, A. reticulata (Annonaceae) [fruit, leaf ], jXelumbo nucifera (Nymphaeaceae)... 

Annonacin Annona muricata (Annonaceae) [seed] ETC - NADH-UQOR... 

Annona muricata L. - graviola Severe insomnia Leaves (infusion or decoction, ingested) Caboclos [56,57] Acetogenins [86,87] neurotoxic benzylisoquinoline derivatives [88] essential oil [89,90] alkaloids [91,92] flavonoids and terpenoids [93] Striatal neurodegeneration [252] atypical parkinsonism [253] antileishmanial activity [254] antidepressive activity [91]... 

Few studies have been found concerning the sedative effect of Annona muricata L. [362] this plant appears to be potentially toxic, which would render use of same difficult [363]. 

Muricatacin 19 (5-hydroxyheptadecan-4-olide) was isolated from Annona muricata (11) as a mixture of (+) and (-) muricatacin with a slight excess of the (-)-enantiomer (4R, 5R) and it is supposed to be a natural (or unnatural) metabolite of acetogenins. It has been shown tha this hydroxy-butyrolactone presents some in vitro cytotoxicity (11). Since its isolation in 1991, many syntheses have been reported in the literature and are discussed herein. 

Corrossolone 161 was isolated from Annona muricata (48). Gromek et al. (9) reported its hemi-synthesis as an diastereomeric mixture at C-15/16/19/20, starting from corepoxylone 5, after treatment with 70 % perchloric acid in acetone. Indeed it has been shown by HPLC that two products, 161 and 162, were obtained, having identical spectroscopic data ( H NMR, 13C NMR, MS). These two compounds arise from the opening of the oxiranes at either C-15 or at C-20 position (Fig. 27). 

The known atherosperminine and thallglucinone have been retsolated from Annona muricata and Thalictrum minus var. microphyllum, respectively. ... 

No. Compound name Annona muricata A reticulata A. atemoya Rollinia mucosa A. montana A. cherimola... 

Although xyloglucans from various plants possess common structural features, the degree and type of side-chain substitution may differ considerably. Xyloglucans isolated from Annona muricata seeds have a (1—>4)- to (1 4,6)-linked glucose ratio of 1.0 0.3, and the polymer is soluble only in... 

The y-lactone natural product muricatacin 1 is a member of the class of biologically active Annonaceous acetogenin family. Muricatacin was isolated from the seeds of Annona muricata L., a variety of apple trees grown commercially in the Caribbean and Central America, by McLaughlin and co-workers in 1991 [1, 2]. Muricatacin exists namrally as a mixture of syn enantiomers in an approximate ratio of 62 38 ( 24 % ee) of (-)-muricatacin (41 , 5R) versus (+)-muricatacin (45, 55) (Fig. 3.1). These 5-hydroxy-y-lactones are comprised of adjacent chiral centres, one of which is incorporated into the lactone framework, with a dodecyl alkyl chain extending from the hydroxy bearing carbon atom. 

Liang, G.H., Xu, A. Tang, H. (1987). Direct generation of wheat haploids via anther culture. Crop Science. Vol.27, No.2, (March-Apail 1987), p>p. 336-339, ISSN 1435-0653 Lemos, E.E.P. Baker, D.A. (1998). Shoot regeneration in respwnse to carbon source on internodal explants of Annona muricata L. Plant Growth Regulation, Vol.25, No.2, 0uly 1998), pp.105-112, ISSN 1573-5087... 

Bories, C., P. Loiseau, D. Cortes, S. H. Myint, R. Hocque-miller, P. Gayral, a. Cave, and A. Laurens, Antiparasitic activity of Annona muricata and Annona cherimolia seeds, Planta Medica, 57, 434-436 (1991). 

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