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Roles of Glutamate in Brain

Erecinska M. and Silver I. A. (1990). Metabolism and role of glutamate in mammalian brain. Prog. Neurobiol. 35 245-296. [Pg.69]

In the literature dangerous for brain neurons effect of ROS was traditionally underestimated — one can believe that multi-step antioxidant system should provide reliable protection. Actually, antioxidants are able to remove toxic component of glutamate overloading and keep neurons viable. However, this point of view is under serious doubt because of both a multiple role of antioxidants in brain metabolism [1,38,52] and apparent absence of therapeutic effect of antioxidant protection [42]. [Pg.163]

Matsuda K, Komune S, Tono T, Yamasaki M, Haruta A, Kato E (2000) A role of glutamate in drug-induced ototoxicity in vivo microdialysis study combined with on-line enzyme fluorometric detection of glutamate in the guinea pig cochlea. Brain Res 852 492-495. [Pg.270]

Fig. 3. Glutdimate cycles in the brain. The scheme shows the roles of glutamate in the brain. In the neuron, glutamate may act as a transmitter, precursor for GABA, or in the metabolic pool. An example is shown of how the three pools can be selectively destroyed in neostriatum. Glutamate is formed from glucose through the citric acid (TCA) cycle, from glutamine or 2-oxoglutarate. The latter two are derived from the glial cells. Fig. 3. Glutdimate cycles in the brain. The scheme shows the roles of glutamate in the brain. In the neuron, glutamate may act as a transmitter, precursor for GABA, or in the metabolic pool. An example is shown of how the three pools can be selectively destroyed in neostriatum. Glutamate is formed from glucose through the citric acid (TCA) cycle, from glutamine or 2-oxoglutarate. The latter two are derived from the glial cells.
Lue A, Brownell W (1999) Salicylate induced changes in outer hair cell lateral wall stiffness. Hear Res 135(1-2) 163-168. doi 10.1016/80378-5955(99)00102-1 Matsuda K, Komune S, Tono T, Yamasaki M, Haruta A, Kato E (2000) A role of glutamate in drug-induced ototoxicity in vivo microdialysis study combined with on-line enzyme fluoro-metric detection of glutamate in the guinea pig cochlea. Brain Res 852(2) 492-495. doi 10. 1016/80006-8993(99)02265-9... [Pg.288]

McDonald, J. W., Shapiro, S. M., Silverstein, F. S. and Johnston, M. V. Role of glutamate receptor-mediated exci-totoxicity in bilirubin-induced brain injury in the Gunn rat model. Exp Neurol. 150 21-29,1998. [Pg.602]

Toth E, Sershen H, et al (1992) Effect of nicotine on extraceUular levels of neurotransmitters assessed by microdialysis in various brain regions role of glutamic acid. Neurochem Res 17(3) 265-271... [Pg.290]

Davis M, Myers KM (2002) The role of glutamate and gamma-aminobutyric acid in fear extinction clinical implications for exposme therapy. Biol Psychiatry 52 998-1007 Davis M, Whalen PJ (2001) The amygdala vigilance and emotion. Mol Psychiatry 6 13-34 Davis M, Hitchcock JM, Bowers MB, Berridge CW, Meha KR, Roth RH (1994) Stress-induced activation of prefrontal cortex dopamine turnover blockade by lesions of the amygdala. Brain Res 664 207-210... [Pg.27]

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