Role in carcinogenesis

Simeonova, P. P. et al., c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic. Role in carcinogenesis, J. Biol. Chem., 277, 2945, 2002. 

S. cerevisiae aurora/IPllp, C. elegans aurora/AIR-2, and mammalian aurora B (also called AIM-1) phosphorylate H3 at Ser-10 and Ser-28 during mitosis [39 1] (Fig. 5). Protein phosphatase 1 removes the phosphate at these sites [39,42]. INCENP is bound to aurora B and is essential for the proper targeting of aurora B on the chromosomes [43-45]. INCENP and aurora B (AIM-1) are overexpressed in a variety of human cancers, including colorectal cancer [43,46]. Overexpression of aurora B (AIM-1) in CHE diploid fibroblasts leads to chromosomal instability, suggesting that aurora B overexpression may play a role in carcinogenesis [46]. INCENP/aurora B and H3 phosphorylation appear to be involved in assembly of mitotic chromosomes, but not mitotic chromosome compaction [44,47]. 

Pelkonen O and Nebert DW Metabolism of polycyclic aromatic hydrocarbons Etiologic role in carcinogenesis. Pharmacol Rev 34 189-222, 1982... 

Counts, J.L. and Goodman, J.I. Alterations in DNA methylation may play a variety of roles in carcinogenesis (1995) Cell 83,13-15... 

The specific interaction of chemicals or radiation with DNA activate cdlular DNA repair processes which appear to play an important role in carcinogenesis. Eukaryotic cells show enhanced repair capacity for repair of viral nucleic add if the host cells are first damaged by chemicals or irradiation. The ihanced susceptibility to cancer of patients with defective repair systems, such as those with xeroderma pigmentosum, suggests that intact repair mechanisms are protective... 

In the previous section we stated that a strong correlation exists between the mutagenic properties of a chemical and its potency as a carcinogen. This is consistent with other evidence that mutation often plays a causal role in carcinogenesis. 

S. Kawanishi, Y. Hiraku and S. Oikawa, Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging, Mutat. Res., 488 (2001) 65-76. 

R. Olinski et al., Oxidative DNA damage Assessment of the role in carcinogenesis, atherosclerosis, and acquired immunodeficiency syndrome. Free Radic. Biol. Med. 33, 192-200 (2002)... 

Safe, S., Molecular biology of the Ah receptor and its role in carcinogenesis, Toxicol. Lett., 120, 1-7, 2001. 

Pelkonen, O., and Ncbert, D. W. (1982). Metabolism of polycyclic aromatic hydrocarbnns Etiological role in carcinogenesis Fharm. Rev. 34, 189-222,... 

Bishop AJ, Schiestl RH. Homologous Recombination and Its Role in Carcinogenesis. / Biomed Biotechnol. 2002 2(2) 75-85. 

Ichikawa, K., Ill insignificant risks, 210, 232-5 International Agency for Research on Cancer (IARC), 114-16, 128, 135 immune system, 78, 90 role in carcinogenesis, 149 immunotoxicity, 67, 90-1 inflammation, 82... 

It is believed that UVR exposure causes skin immune suppression. Both UVB and UVA have been implicated (292). A possible mechanism is UVA-induced lipid peroxidation, which results in the migration of immune-mediating cells from the epidermis and therefore leads to skin immune suppression (224). It has been suggested that skin immune suppression plays a role in carcinogenesis. However, the relationship between the two is not well understood yet (293). 

Sawa, T. and Ohshima, H. (2006) Nitrative DNA damage in inflammation and its possible role in carcinogenesis. Nitric Oxide, 14, 91-100. 

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