Role of PARP in Human Carcinogenesis

Carcint nesis in humans generally increases dramatically with age and it is considered that five or mote genetic or epigenetic events may be necessary for development of cancer. Each 

The identification of iwous Pup family members as well as Pa evoked inti uing questions on their functions, including whether these proteins are related to carcinogenesis, and further studies using animal models should clarify the impact of their deficiency on susceptibility to carcinogenesis. 

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Masutani M, Nakagama H, Sugimura T. Poly(ADP-ribose) and carcinogenesis. Genes Chromosomes Cancer 2003 38(4) 339-348. 

Masutani M, Suzuki H, Kamada N et al. PolyfADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocln-induced diabetes. Proc Nad Acad Sci USA 1999 96(5) 2301-2304. 

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