Rickettsial diseases

Bayne-Jones, S., Am. Assoc. Advancement Sci., Sect. Med. Sci., Rickettsial Diseases of Man,... 

Differential Diagnosis Thrombocytopenia (a condition in which there is an abnormally small number of platelets in the circulating blood) and an elevated aspartate aminotransferase (AST) may provide a clue to suggest CCHF is the culprit in the febrile (denoting or relating to fever) patient seen early in the course of infection. Other viral hemorrhagic fevers, meningococcemia, rickettsial diseases, and similar conditions may resemble full-... 

Chloramphenicol is an alternative to tetracycline for rickettsial diseases, especially in children younger than... 

Merck, The Merck Manual of Diagnosis and Therapy. Section 13. Infectious Diseases. Chapter 159. Rickettsial Diseases (www mcrck com [nibs nimamial section 13 cliaptcrl 59 159a. 111 nl)... 

Other viral hemorrhagic fevers Rickettsial diseases Typhoid fever... 

Dumler JS, Walker DH. Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases. Dermat Clin. 1994 12 25-36. 

Chapman AS, Bakken JS, Folk SM, et al. Diagnosis and management of tickborne rickettsial diseases Rocky Mountain spotted fever, ehrlichiosis, and anaplasmosis—United States A practical guide for physicians and other health-care and public health professionals. MMWR Recomm Rep. 2006 55 1-27. 

Tetracyclines usually are the preferred agents for the treatment of rickettsial diseases. In patients allergic to these drugs, in those with reduced renal function, in pregnant women, and in children <8 years of age who require prolonged or repeated courses of therapy, chloramphenicol may be the drug of choice. Rickettsial diseases, such as Rocky Mountain spotted fever, respond well to chloramphenicol. For adults, a dose of 50 mg/kg/day is recommended for all the rickettsial diseases. The daily dose of chloramphenicol for children with these diseases is 75 mg/kg, divided into equal portions and given every 6-8 hours. Therapy should be continued until the patient has improved and is afebrile for 24—48 hours. 

Benenson AS. Q fever vaccine Efficacy and present status. In Smadel JE, ed. Symposium on Q fever by the Committee on Rickettsial Diseases. Washington, DC Armed Forces Epidemiology Board 1959 47-60. 

Chloramphenicol was the first broad-spectrum antibiotic to be used in medicine, but it came under a cloud when long-continued administration produced many cases of aplastic anaemia, which can be life endangering. Its use is now restricted to diseases where it is the most active known remedy, and which are likely to be cured quickly, within the safe period of the drug. Hence it is used to cure typhoid fever, bacterial meningitis, and anaerobic infections of the brain such as those caused by B.fragilis. It is the only common antibiotic to pass freely into the cerebrospinal fluid and to cross the blood—brain barrier. It also serves as a useful alternative to the tetracyclines in cholera and the rickettsial diseases such as typhus or Rocky Mountain spotted fever. 

Bartonellosis Rickettsial disease, caused by Bartonella bacilliformisy that occurs in two forms. 

Epidemic typhus Louseborne rickettsial disease caused by Rickettsia prowazekii, seen most frequently in conditions of overcrowding and poor sanitation. 

Petechia (plural petechiae). A pinpoint-size hemorrhage, most common in skin folds, that often occurs in rickettsial diseases. 

Rickettsialpox Mild rickettsial disease with symptoms resembling those of chickenpox caused by Rickettsia akari and carried by mites found on house mice. 

Trench fever Rickettsial disease, caused by Rochalimaea quintana, resembling... 

Typhus fever Rickettsial disease that occurs in a variety of forms including epidemic, endemic (murine), and scrub typhus. 

IMMUNITY IN VIRAL AND RICKETTSIAL DISEASES Edited by A. Kohn and M. A. Klingberg 1973... 

Antirickettsial. PABA is sometimes used in the treatment of certain rickettsial diseases—diseases in man and animals caused by microscopically small parasites of the genus Rickettsia, notably typhus and Rocky Mountain spotted fever. 

The therapeutic use of PABA in the treatment of rickettsial diseases is based on the concept of metabolic antagonism. PABA acts as an antagonist to a material essential to these organisms, para-oxybenzoic acid hence, the rickettsial organisms are killed because PABA blocks their essential metabolite. 

Trench Fever Rickettsial disease, ceaised hy Rochalimaea Quintana, resembling epidemic typhus in that is transmitted by lice and is prevalent during wars and under unsanitary conditions. Known also as Shinbone Fever. 

Viral and Rickettsial Disease Laboratory. 1986. Laboratory Safety Guidelines Viral and Rickettsial Disease Laboratory. California State Department of Health, Berkeley, CA. 

Rickettsial diseases including spotted fevers and Q fever Tularaemia Lyme borreliosis Relapsing fever, borreliosis Scrub typhus... 

M. (2011) Oral vaccination of Atlantic salmon (Salmo solar) against salmonid rickettsial disease. Vaccine 29, 2336-2340. 

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