Respiratory tract/system inhaled

Health Hazard Information - Recommended Personal Protective Equipment Goggles or face shield plastic gloves (as for gasoline) Symptoms Following Exposure Vapor causes mild irritation of eyes and mild Irritation of respiratory tract if inhaled. Ingestion causes irritation to stomach. Aspiration causes severe lung irritation and rapidly developing pulmonary edema central nervous system excitement... 

Oxalic acid exposure typically produces immediate irritation and local effects on the skin, eyes, and mucosal membranes of the gastrointestinal tract (if ingested) or respiratory tract (if inhaled). Slightly delayed effects may occur on the respiratory system and kidneys. 

Codd R, Lay PA. 2003. Oxochromium(V) species formed with 2,3-dehydro-2-deoxy-N-acetylneuraminic or N-acetylneuraminic (sialic) acids an in vitro model system of oxochromium(V) species potentially stabilized in the respiratory tract upon inhalation of carcinogenic chromium(VI) compounds. Chem Res Toxicol 16(7) 881—892. Signorella S, Garcia S, Rizzotto M, Levina A, Lay PA, Sala LF. 2005. The EPR pattern of Cr complexes of D-ribose derivatives. Polyhedron 24(9) 1079-1085. 

Inhalation is the primary route for occupational nickel exposure. Inhalation exposure to some nickel compounds cause toxic effects in the respiratory tract and immune system. Acute inhalation exposure of humans to nickel may produce headache, nausea, respiratory disorders, and death. Asthmatic conditions have also been documented for inhalation exposure to nickel. Data on nickel-induced reproductive/developmental effects in humans following inhalation exposure are mixed, with some studies pointing to reproductive effects from inhalation exposure to nickel, while other studies found no observable effects. The primary target organs for nickel-induced systemic toxicity are the lungs and upper respiratory tract for inhalation exposure and the kidneys for oral exposure. Other target organs include the cardiovascular system, immune system, and the blood. 

Hydraziae is toxic and readily absorbed by oral, dermal, or inhalation routes of exposure. Contact with hydraziae irritates the skin, eyes, and respiratory tract. Liquid splashed iato the eyes may cause permanent damage to the cornea. At high doses it can cause convulsions, but even low doses may result ia ceatral aervous system depressioa. Death from acute exposure results from coavulsioas, respiratory arrest, and cardiovascular coUapse. Repeated exposure may affect the lungs, Hver, and kidneys. Of the hydraziae derivatives studied, 1,1-dimethylhydrazine (UDMH) appears to be the least hepatotoxic monomethyl-hydrazine (MMH) seems to be more toxic to the kidneys. Evidence is limited as to the effect of hydraziae oa reproductioa and/or development however, animal studies demonstrate that only doses that produce toxicity ia pregaant rats result ia embryotoxicity (164). 

Propylene oxide is a primary irritant, a mild protoplasmic poison, and a mild depressant of the central nervous system. Skin contact, even in dilute solution (1%), may cause irritation to the eyes, respiratory tract, and lungs. Propylene oxide is a suspected carcinogen in animals. The LC q (lowest lethal concentration by inhalation in tats) is 4000 mg/kg body weight. The LD q (oral) is 930 mg/kg. The LD q (dermal) is 1500 mg/kg. The TWA (8-h exposure) is 100 ppm and the STEP (15-min exposure) is 150 ppm. 

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