Reproductive and fertility effects

EPA, U.S. Environmental Protection Agency, Reproductive and Fertility Effects, Health Effects Test Guidelines, OPPTS 870.3800, EPA712-C-98-208,1998b. http //www.epa.gov /opptsfrs/OPPTS Harmonized/870 Health Effects Test Guidelines/Series/870-6300. pdf... [Pg.339]

US EPA (Environmental Protection Agency), OPPTS (Office of Prevention, Pesticides and Toxic Substances). (1998) Health effects test guidelines. OPPTS 870.3800. Reproduction and fertility effects... [Pg.293]

Gaoua W (2004b) Ethyl tertiary butyl ether (ETBE) Two-generation study (reproduction and fertility effects) by the oral route (gavage) in rats. CIT Study No. 24859 RSR, unpublished study for Totalfinaelf on behalf of the ETBE Producers Consortium... [Pg.392]

U.S. Environmental Protection Agency (I998d). Health effects lest guidelines, OPPTS 870.38(X>, Reproduction and Fertility Effects. EPA 712-C-98-208. U.S. Environmental Protection Agency, Washington, DC. [Pg.642]

Sub-chronic and chronic toxicity tests provide an in-depth look at a number of organ systems, prenatal developmental toxicity and reproduction and fertility effects. A complete set of all these tests is available at the integrated risk information system (IRIS) of EPA [14]. [Pg.434]

Coppola, D. M. and Vandenbergh, J. G. (1985). Effect of density, duration of grouping and age of urine stimulus on the puberty delay pheromone in female mice. Journal of Reproduction and Fertility 73,517. [Pg.448]

In a 6-month study of rats, oral doses of 2.7 or 25mg/kg/day caused no hepatic changes. A two-generation study of reproduction and fertility in rats used oral doses of 2, 7, or 25mg/kg/day." Maternal toxicity was observed. Decreases in dam weight, number of corpora lutea, number of implantations, and number of neonates was attributable to the toxic effects in the dams. There were no findings in the Fi generation. [Pg.190]

The National Toxicology Program (NTP) is performing subchronic tests of cresol toxicity in which either o-cresol or mixed cresol isomers are given to rats and mice in the feed. In addition, studies of the effects of cresols on reproduction and fertility in mice are being performed by the NTP. The results of these studies are not yet available. [Pg.71]

Chemical-induced reproductive toxicity consists of effects on reproductive performance (e.g., fertility and fecundity), the reproductive tract, and/or sexual development. Reproductive toxicity has been routinely assessed, using laboratory animal studies, in the chemical risk assessment process for over 40 years. For environmental chemicals, the multigeneration reproduction and fertility study in rats has been the primary tool for assessing reproductive toxicity potential in humans. Unfortunately, these expensive and animal-intensive studies have only been conducted on a fraction of environmentally... [Pg.354]

Aim C C, Sullivan J J, First N L 1975 The effect of a corticosteroid (dexamethasone), progesterone, oestrogen and prostagiandin F2 on gestation iength in normal and ovariectomized mares. Journal of Reproduction and Fertility Supplements 23 637-640 Amann R P 1993 Effects of drugs or toxins on... [Pg.189]

Ousey J C, Rossdale P D, Palmer L et al 2000 Effects of maternally administered depot ACTH(1-24) on fetal maturation and the timing of parturition in the mare. Equine Veterinary Journal 32 489-496 Pashen R L 1982 Oxytocin the induction agent of choice in the mare Journal of Reproduction and Fertility Supplements 32 645... [Pg.190]

Kennedy GL Jr. (2001) Biological effects of acetamide, formamide, and their monomethyl and dimethyl derivatives an update. Critical Reviews in Toxicology 31 139. Thiersch JB (1962) Effects of acetamides and formamides on the rat litter in vitro. Journal of Reproduction and Fertility 4 219. [Pg.1189]

Bushy Run Research Center 1985. Potential effects of nitrobenzene inhalation on reproduction and fertility in rats. Submitted to Nitrobenzene Association. Project Report 47-524. Unpublished. [Pg.76]

Harper, M.J. and Walpole, A.L. (1967) A new derivative oftriphenylethylene effect on implantation and mode of action in rats. Journal of Reproduction and Fertility, 13, 101-119. [Pg.179]

Bisphenol A causes adverse reproductive and developmental effects in animal studies. But, is the weight of evidence sufficient to consider bisphenol A of high or moderate concern for reproductive and/or developmental toxicity In 2003, the European Union concluded that bisphenol A may adversely affect fertility (reproductive toxic) and that low dose studies indicate bisphenol A may be a development toxicant. Since the EU risk assessment of bisphenol A, a significant body of experimental data has been published evaluating the toxicity potential of bisphenol A at low doses. There is considerable debate on which studies are relevant for evaluating low dose effects of bisphenol A. Issues in the debate include the type of animal studied (the Charles River-Sprague Dawley rat, for example, is the least sensitive test animal to estrogenic chemicals), the... [Pg.36]

In addition numerous multigeneration fertility studies have been carried out on many different phthalates. The most recent of these are two-generation studies which demonstrate that exposure of rats to di-isononyl phthalate (DINF) [23] and DIDF [24] in utero, during lactation, puberty and adulthood does not affect testicular size, sperm count, morphology or motility or produce any reproductive or fertility effects. No outcome which might be anticipated from hormone modulation was observed. The maximum level dosed was around 600mg/kg bw/day. [Pg.509]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...