Removal of Cleaning Agents

TABLE 7 Amount of Cephalosporin Residue on Surfaces Which Were Exposed to Milligram Quantities of Cephalospsorin and Cleaned 

FIGURE 5 Typical chromatogram ofswab blank, swab sample, and standard preparation. 

TABLE 8 Recovery of Triton X-100 from 316,316L, and 304 Stainless-Steel Surfaces 

Analytical Methodology The Heart of Cleaning Validation, Presented at the 42nd Annual Conference on Pharmaceutical Analysis, July 30, 2002, Merrimac, Wisconsin and 26th Puerto Rico Pharmaceutical Quality Association, January 28,2003, San Juan, Puerto Rico. 

Rotsch, T. D., Spanton, M., Cugier, P. and Plasz, A. C., Determination of Clarithromycin as a Contaminant on Surfaces by High Performance Liquid Chromatography Using Electrochemical Detection, Pharm. Res., 8 989-991, 1991. 

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Removal of cleaning agents at the end of the cleaning procedure should be validated. Validated cleaning procedures should be used. 

Tribasic sodium phosphate is used in a variety of cleaning agents, such as detergents, industrial cleaning products, and metal cleaners to treat boiler water for the tanning of leather in the manufacture of textiles and paper products in the purification of sugar as a dietary supplement for humans and farm animals in paint removers and for various photographic purposes. 

Eowler, D. E., and E. T. Mcllvaine. 1989. Removal of toxic agents from trichlorotri-flnoroethane cleaning solvents. U.S. Patent 4,842,746, Jnne 27 cited in Chem. Abstr. CA III (IS) 159675T... 

There are some occasions where it is necessary to apply solvents to plastics, for example removal of residues from adhesive labels or earlier repairs. Selection of liquids to clean plastics surfaces, which will not soften or dissolve them, may be achieved in two ways. The trial and error approach involves applying drops of cleaning agents to a test piece or a hidden area of the object and examining the results with time. A more systematic approach is to compare the polarity of the liquid with that of the plastic in order to avoid those liquids which are most likely to dissolve or soften the object. 

It is important to carry out adequate final rinsing with demineralized water in order to remove any remaining traces of cleaning agents which would inhibit growth. 

Aquanox AA4512/ Kyzen Batch or in-line spray removal of Concentrated agent for aqueous many flux residues and uncured cleaning adhesive (5%-20% concentration range, operating range 49°C-71°C 99-101 N/A N/A N/A N/A... 

The acid cleaning procedure removes oxides and other contaminants by immersion in a suitable acid solution, usually at room temperature. The type of cleaning agent selected will depend, in most cases, on the material to be cleaned. The following general guidelines can be used ... 

The top of the bench should always be kept clean and dry this can easily be done if a wet and a dry rag are kept at hand. Apparatus not immediately required (a) should be kept as far as possible in a cupboard beneath the bench if it must be placed on the bench, it should be arranged in a neat and orderly manner. All apparatus should be washed immediately after use and placed in a position to drain at the first opportunity, the apparatus should be dried. It must be emphasised that as a general rule a deposit of dirt or tar is more easily removed when it is freshly formed a suitable cleaning agent can usually be found while one still remembers the nature of the material or the circumstances attending its formation. It is hardly necessary to add that sohd waste and filter papers must not be thrown into the sink, and that all operations requiring the handhng of unpleasant and noxious materials sliould be carried out in the fume cupboard ( hood ). 

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