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Ahnert-Hilger G, Weller U, Dauzenroth ME, ef al. (1989a) The tetanus toxin light chain inhibits exocytosis. FEBS Left. 242 245—8. [Pg.211]

Ahnert-Hilger G, Bader MF, BhakDai S et al. (1989b) Introduction of macromolecules into bovine adrenal medullary chromaffin cells and rat pheochromocy-toma cells (PC12) by permeabilization with streptolysin O inhibitory effect of tetanus toxin on catecholamine secretion. J. Neurochem. 52 1751 -8 [Pg.211]

Ahnert-Hilger G, Dauzenroth ME, Habermann E et al. (1990) Chains and fragments of tetanus toxin, and their contribution to toxicity. J. Physiol. (Paris) 84 229-36. [Pg.211]

Ahnert-Hilger G, Bigalke H (1995) Molecular aspects of tetanus and botulinum neurotoxin poisoning. Prog. Neurobiol. 46 83-96. [Pg.211]

Angaut-Petit D, Molgo J, Cornelia JX etal. (1990) Terminal sprouting in mouse neuromuscular junctions poisoned with botulinum type A toxin morphological and electrophysiological features. Neuroscience. 37 799-808. [Pg.211]


The particle-in-a-box problem provides an important model for several relevant chemical situations... [Pg.21]

The first qualitatively correct attempt to model the relevant chemical potentials in a polymer solution was made independently by Huggins (4, ) and Flory [6). Their models, which are similar except for nomenclature, are now usually called the Flory-Huggins model ( ). [Pg.185]

To this point, we have emphasized that the cycle of mobilization, transport, and redeposition involves changes in the physical state and chemical form of the elements, and that the ultimate distribution of an element among different chemical species can be described by thermochemical equilibrium data. Equilibrium calculations describe the potential for change between two end states, and only in certain cases can they provide information about rates (Hoffman, 1981). In analyzing and modeling a geochemical system, a decision must be made as to whether an equilibrium or non-equilibrium model is appropriate. The choice depends on the time scales involved, and specifically on the ratio of the rate of the relevant chemical transition to the rate of the dominant physical process within the physical-chemical system. [Pg.401]

International Chemical Safety Cards on the relevant chemical(s) are attached at the end of the CICAD, to provide the reader with concise information on the protection of human health and on emergency action. They are produced in a separate peer-reviewed procedure at IPCS. They may be complemented by information from IPCS Poison Information Monographs (PIM), similarly produced separately from the CICAD process. [Pg.1]

How does this understanding of molecular mechanisms of nitrosamlne formation help us solve the practical problem of controlling any contamination associated with the production, storage, or use of pesticides Let us look at two excellent examples of relevant chemical problem-solving. [Pg.136]

Determination of potential intake by analyzing consnmption patterns of individual foods containing the relevant chemical. This aspect shonld evaluate how much of a food containing the relevant snbstance is consumed, with particular attention paid to risk gronps. [Pg.567]

Approaching the subject from a practical point of view, how many plants actually are performing safety-relevant chemical processes. In an older study, the share of safety-relevant plants in the German state of Rhineland-Palatinate are listed [173]. It is assumed here that the trend given there still is valid. [Pg.75]

The offset a, and the multiplication constant bj are estimated by simple linear regression of the ith individual spectrum on the reference spectrum z. For the latter one may take the average of all spectra. The deviation e, from this fit carries the unique information. This deviation, after division by the multiplication constant, is used in the subsequent multivariate calibration. For the above correction it is not mandatory to use the entire spectral region. In fact, it is better to compute the offset and the slope from those parts of the wavelength range that contain no relevant chemical information. However, this requires spectroscopic knowledge that is not always available. [Pg.373]

Appendix B covers some relevant chemical and physical concepts used in the book. [Pg.229]

The term biology-oriented synthesis (BIOS) [45] has been used to describe the design of compound libraries based on biologically relevant chemical space [46]. The areas in protein structures that participate in productive protein-ligand interactions have been, for the most part, already defined by natural products and drugs. Thus libraries inspired by natural products and other bioactive molecules are expected to have a higher probability of biologically activity than randomly synthesized molecules [47,48]. [Pg.415]

The lack of precise measurements of environmentally relevant chemical rate constants limits the number of quantitative evaluations of the importance of complex dynamics on uptake fluxes. Nonetheless, examples involving bicarbon-ate-CC>2 conversion [69,88] and trace metal complexation [8,46,325] have been examined theoretically in the literature. For example, comparison of the diffu-sional and reactional timescale allowed Riebesell and collaborators [69,88] to show that bicarbonate conversion to CO2 did not generally enhance the... [Pg.503]

The aim of this chapter is to illustrate with some representative examples the relationship between the two deeply connected phenomena of aromaticity and chemical reactivity. The coverage of the considerable theoretical work done on the relationship between aromaticity and chemical reactivity is extensive, but is not exhaustive. Rather, we confine our discussion to the most relevant chemical reactions. Section 28.2 is devoted to the current and most widely used descriptors of aromaticity. The complex relation between aromaticity and stability is analyzed in Section 28.3. Section 28.4 discusses the most relevant chemical reactions for which one of the main driving forces is aromaticity. And finally, in Section 28.5, the most important findings are briefly summarized. [Pg.422]

Lobelia contains 14 alkaloids, of which lobeline is the most significant (figure 4.13). Other alkaloids include lobelanine, lobelanidine, norlobelanine, and isolobinine. Another relevant chemical that is isolated from the leaves of lobelia is beta-amyrin palmitate. [Pg.123]

Because of the enormous synthetic potential of molybdenum- [22] and ruthenium-based [57,806] single-component catalysts, a closer look at the scope and limitations of the most promising compounds known to date is appropriate. The systematic exploration of the synthetic possibilities offered by these new catalysts has just begun, and many new developments are to be expected in the near future [744,746,747,807]. As quick reference for the organic chemist, the most relevant chemical properties of two types of frequently used catalyst (Figure 3.46) are listed below. These carbene complexes are quite robust and well-suited to the metathesis of elaborate organic intermediates. [Pg.143]

The European Food Safety Authority (EESA) (2006) Advice of the scientific panel on contaminants in the food chain on a request from the Commission related to relevant chemical compounds in the group of hrominated flame retardants for monitoring in feed and food. EFSA J 328 1. http //www.efsa.europe.eu... [Pg.288]

The fundamental problems of accelerated performance testing are the selection of appropriate test conditions, and the determination and validation of acceleration factors. Ideally test conditions should be selected to accelerate all the relevant chemical reactions and physical processes equally. The determination of acceleration factors typically requires, and hence poses the same problems as, performance tests under natural exposure conditions. [Pg.6]

Such pentacarbonyl species can be further decarbonylated when the sample is heated to 373 K under an inert gas stream and under reduced pressure. This slow decarbonylation process provides the surface Mo(CO)3 species depicted in Figure 9.4, which is stable up to 473 K [14]. In contrast with the relevant chemical behavior in solution (9.1 and 9.2), in the solid state, where the species are somewhat diluted and present low mobility, no dimeric species have been identified as resulting from penta- or tricarbonyl species. Heating to 673 K gives rise to the evolution of H2, CO, CO2 and CH4, due to redox reactions between the metal center and the OH surface groups. The resulting oxidation states, as determined by XPS measurements, are mainly II and IV, besides some Mo(0) species ]20]. It is worth underHn-... [Pg.355]


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